肝脏假期？每日或非每日饮酒相同量与肝硬化风险的荟萃分析。
Liver holidays? A meta-analysis of drinking the same amount of alcohol daily or non-daily and the risk for cirrhosis.
机构信息
Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
出版信息
Drug Alcohol Rev. 2023 Jan;42(1):119-124. doi: 10.1111/dar.13563. Epub 2022 Oct 24.
INTRODUCTION
Several alcohol drinking guidelines indicate that daily alcohol consumption should be avoided because of its negative impact on the liver and to avoid the development of alcohol use disorders. Evidence that supports this recommendation is scarce. Our aim was to compare daily versus non-daily drinking and its association with liver cirrhosis.
METHODS
We conducted a review using PubMed/Medline and Embase as databases, selecting longitudinal or case control studies. A random effects meta-analysis was conducted.
RESULTS
Five mainly large-scale studies were retrieved. Daily drinking was associated with a significant increase in risk of liver cirrhosis compared to non-daily drinking, with a pooled relative risks of 1.71 (95% confidence interval 1.23-2.23) for men and 1.56 (95% confidence interval 1.39-1.74) for women.
DISCUSSION AND CONCLUSIONS
The consistent exposure to acetaldehyde and other toxins for daily drinkers may explain our findings. There should be days of abstinence to allow the liver to recover, especially for heavier drinkers.
简介
一些关于饮酒的指导方针表明，应避免每日饮酒，因为这会对肝脏造成负面影响，并可能导致酒精使用障碍。支持这一建议的证据很少。我们的目的是比较每日饮酒和非每日饮酒及其与肝硬化的关系。
方法
我们使用 PubMed/Medline 和 Embase 作为数据库进行了综述，选择了纵向或病例对照研究。进行了随机效应荟萃分析。
结果
共检索到五项主要的大规模研究。与非每日饮酒相比，每日饮酒与肝硬化风险显著增加相关，男性的 pooled relative risks 为 1.71（95%置信区间 1.23-2.23），女性为 1.56（95%置信区间 1.39-1.74）。
讨论和结论
每日饮酒者持续暴露于乙醛和其他毒素可能解释了我们的发现。应该有几天的戒酒期，让肝脏得到恢复，特别是对于饮酒量较大的人。
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