Department of Hepatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK-2100, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen DK-1353, Denmark.
National Institute of Public Health, University of Southern Denmark, Copenhagen DK-1353, Denmark.
J Hepatol. 2015 May;62(5):1061-7. doi: 10.1016/j.jhep.2014.12.005. Epub 2015 Jan 26.
BACKGROUND & AIMS: Alcohol is the main contributing factor of alcoholic cirrhosis, but less is known about the significance of drinking pattern.
We investigated the risk of alcoholic cirrhosis among 55,917 participants (aged 50-64 years) in the Danish Cancer, Diet, and Health study (1993-2011). Baseline information on alcohol intake, drinking pattern, and confounders was obtained from a questionnaire. Follow-up information came from national registers. We calculated hazard ratios (HRs) for alcoholic cirrhosis in relation to drinking frequency, lifetime alcohol amount, and beverage type.
We observed 257 and 85 incident cases of alcoholic cirrhosis among men and women, respectively, none among lifetime abstainers. In men, HR for alcoholic cirrhosis among daily drinkers was 3.65 (95% CI: 2.39; 5.55) compared to drinking 2-4 days/week. Alcohol amount in recent age periods (40-49 and 50-59 years) was associated with an increased risk, whereas the amount in 20-29 and 30-39 years was not. In men drinking 14-28 drinks/week, HR was 7.47 (95% CI: 1.68; 33.12), 3.12 (95% CI: 1.53; 6.39), and 1.69 (95% CI: 0.79; 3.65) in drinkers of little (<1% of weekly amount), some (1-15%), and mostly wine (50-100%), compared to drinking <14 drinks/week. In general, results were similar for women.
In men, daily drinking was associated with an increased risk of alcoholic cirrhosis. Recent alcohol consumption rather than earlier in life was associated with risk of alcoholic cirrhosis. Compared to beer and liquor, wine might be associated with a lower risk of alcoholic cirrhosis.
酒精是导致酒精性肝硬化的主要因素，但对于饮酒模式的重要性知之甚少。
我们调查了丹麦癌症、饮食和健康研究（1993-2011 年）中 55917 名（年龄 50-64 岁）参与者患酒精性肝硬化的风险。酒精摄入量、饮酒模式和混杂因素的基线信息来自问卷调查。随访信息来自国家登记处。我们计算了与饮酒频率、终生饮酒量和饮料类型相关的酒精性肝硬化风险的危害比（HRs）。
我们观察到男性分别有 257 例和 85 例酒精性肝硬化新发病例，而终生戒酒者中无一例发病。在男性中，与每周饮酒 2-4 天相比，每日饮酒者患酒精性肝硬化的 HR 为 3.65（95%CI：2.39；5.55）。最近年龄段（40-49 岁和 50-59 岁）的饮酒量与风险增加相关，而 20-29 岁和 30-39 岁的饮酒量则不然。在每周饮酒 14-28 杯的男性中，HR 分别为 7.47（95%CI：1.68；33.12）、3.12（95%CI：1.53；6.39）和 1.69（95%CI：0.79；3.65），与每周饮酒量<14 杯的饮酒者相比，饮用少量（<1%的周饮用量）、一些（1-15%）和大部分（50-100%）葡萄酒的饮酒者风险更高。总体而言，女性的结果相似。
在男性中，每日饮酒与酒精性肝硬化风险增加相关。近期饮酒而不是早年饮酒与酒精性肝硬化风险相关。与啤酒和白酒相比，葡萄酒可能与较低的酒精性肝硬化风险相关。
