Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), Universitat Politècnica de València (UPV), Universitat de València (UV), Valencia, Spain.
ITIS Foundation for Research on Information Technologies in Society, Zurich, Switzerland; Swiss Federal Institute of Technology (ETHZ), Zurich, Switzerland.
Comput Methods Programs Biomed. 2022 Nov;226:107185. doi: 10.1016/j.cmpb.2022.107185. Epub 2022 Oct 17.
Hyperthermia is a cancer treatment aiming to induce cell death by directly warming cancerous tissues above 40 °C. This technique can be applied both individually and together with other cancer therapies. The main challenge for researchers and medics is to heat only tumoral cells avoiding global or localized heating of sane tissues. The objective in this study is to provide a realistic virtual scenario to develop an optimized multi-site injection plan for tailored magnetic nanoparticle-mediated hyperthermia applications.
A three-dimensional model of a cat's back was tested in three different simulation scenarios, showing the impact of magnetic nanoparticles in each specific environment configuration.
As a result of this study. This simulation method can, minimising the affection to healthy tissue.
This virtual method will help real and personalized therapy planning and tailor the dose and distribution of magnetic nanoparticles for an enhanced hyperthermia cancer treatment.
热疗是一种通过将癌变组织直接加热至 40°C 以上来诱导细胞死亡的癌症治疗方法。这种技术可以单独使用，也可以与其他癌症治疗方法联合使用。研究人员和医务人员面临的主要挑战是仅加热肿瘤细胞，避免正常组织的全局或局部加热。本研究的目的是提供一个现实的虚拟场景，以开发优化的多部位注射计划，用于定制基于磁性纳米颗粒的热疗应用。
在三个不同的模拟场景中测试了猫背部的三维模型，展示了磁性纳米颗粒在每种特定环境配置下的影响。
通过这项研究，这种模拟方法可以最小化对健康组织的影响。
这种虚拟方法将有助于进行真实和个性化的治疗计划，并为增强癌症热疗量身定制磁性纳米颗粒的剂量和分布。
