Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn.
J Thorac Cardiovasc Surg. 2024 Jun;167(6):2091-2101. doi: 10.1016/j.jtcvs.2022.09.035. Epub 2022 Sep 26.
In patients undergoing mitral valve surgery, optimal management of less-than-severe concomitant tricuspid valve regurgitation (TR) is unclear, as there are few long-term data. This study examines progression of TR, patient survival, and reoperations in patients undergoing mitral valve surgery.
There were 1588 patients who underwent degenerative mitral valve surgery and had pre- and postoperative echocardiograms for assessment of TR severity and tricuspid annulus diameter. Analysis used repeated-measures ordinal regression to model the longitudinal trends in TR grade and proportional hazards regression for long-term survival and reoperation outcomes.
Concomitant tricuspid valve (TV) surgery was performed in 235 (14.8%) patients. In response to surgery, TR grades improved more in patients with concomitant TV intervention regardless of the severity of preoperative TR, and these early trends were sustained over long-term follow-up. Risk of progression to severe TR was not influenced by tricuspid annulus diameter (P = .226). After we adjusted for underlying health characteristics, survival following mitral valve surgery was similar in patients with and without TV intervention. Late TV reoperation was observed in 22 patients (5-year cumulative risk 1.5%), but among these, only 6 patients had severe TR as the primary indication for reoperation; preoperative TR grade and initial concomitant TV surgery were not associated with incidence of reoperation.
Concomitant TV surgery for moderate TR reduces progression of TR but did not influence survival or incidence of reoperation. Among patients with less-than-severe preoperative TR, tricuspid annular diameter was not associated with progression to severe TR.
在接受二尖瓣手术的患者中,对于轻度以下的三尖瓣反流(TR)的最佳处理方法尚不清楚,因为长期数据很少。本研究检查了二尖瓣手术后 TR 的进展、患者生存和再次手术的情况。
有 1588 名患者接受退行性二尖瓣手术,并进行了术前和术后超声心动图检查,以评估 TR 严重程度和三尖瓣环直径。分析采用重复测量有序回归来模拟 TR 分级的纵向趋势,采用比例风险回归来评估长期生存和再次手术的结果。
235 名(14.8%)患者同时行三尖瓣(TV)手术。无论术前 TR 的严重程度如何,在同时进行 TV 干预的患者中,TR 分级的改善更为明显,这些早期趋势在长期随访中得以维持。三尖瓣环直径(P =.226)并不影响进展为重度 TR 的风险。在调整了基础健康特征后,二尖瓣手术后的生存率在有 TV 干预和无 TV 干预的患者中相似。22 例患者(5 年累积风险 1.5%)出现晚期 TV 再次手术,但其中只有 6 例患者因重度 TR 作为再次手术的主要指征;术前 TR 分级和初始同时行 TV 手术与再次手术的发生率无关。
中度 TR 的同时 TV 手术可减少 TR 的进展,但不影响生存或再次手术的发生率。在术前 TR 较轻的患者中,三尖瓣环直径与进展为重度 TR 无关。