Department of Medicine, Aga khan University, Karachi, Pakistan.
Department of Medicine, Aga Khan University, Karachi.
J Pak Med Assoc. 2022 Aug;72(8):1491-1496. doi: 10.47391/JPMA.2382.
To identify the local patterns of manifestations, organ involvement other than lungs, diagnostic tools and treatment regimens related to patients of sarcoidosis.
The retrospective study was conducted from November 1, 2019, to February 28, 2020, at the Aga Khan University Hospital, Karachi, and comprised data of sarcoidosis patients who needed hospitalisation between 2009 and 2019. The entire clinical spectrum was noted based on organ involvement. Data was analysed using SPSS 21.
Of the 80 patients, 53(66.3%) were women. The overall mean age at diagnosis was 52.0±13.5 years. Pulmonary sarcoidosis was found in 60(75%) patients, while 13(16.3%) had extrapulmonary manifestations, and 6(8.8%) had both pulmonary and extrapulmonary involvement. None of the patients had hypercalcaemia, while antinuclear antibodies were positive in 2 (18.2%) patients. In terms of treatment, 75(93.8%) patients received corticosteroids. Acute exacerbation of interstitial lung disease was the most common reason of hospitalisation 16(20%). Mortality was the outcome in 11(14.7%) cases.
Sarcoidosis was found to be more prevalent in women aged 50 years and above. A quarter of patients had extrapulmonary manifestation, while interstitial lung disease was the most common complication.
确定结节病患者的局部表现、肺部以外的器官受累、诊断工具和治疗方案的本地模式。
本回顾性研究于 2019 年 11 月 1 日至 2020 年 2 月 28 日在卡拉奇的 Aga Khan 大学医院进行，纳入了 2009 年至 2019 年期间需要住院治疗的结节病患者的数据。根据器官受累情况记录了整个临床谱。使用 SPSS 21 进行数据分析。
80 例患者中，53 例（66.3%）为女性。总体诊断时的平均年龄为 52.0±13.5 岁。60 例（75%）患者患有肺部结节病，13 例（16.3%）有肺外表现，6 例（8.8%）有肺部和肺外表现。无高钙血症患者，2 例（18.2%）患者抗核抗体阳性。在治疗方面，75 例（93.8%）患者接受了皮质类固醇治疗。间质性肺病急性加重是住院的最常见原因，共 16 例（20%）。11 例（14.7%）患者死亡。
结节病在 50 岁及以上的女性中更为常见。四分之一的患者有肺外表现，而间质性肺病是最常见的并发症。
