Department of Geriatric Oncology, Jiangnan Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine (Xiaoshan Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.
Department of Pediatrics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Medicine (Baltimore). 2022 Oct 21;101(42):e31280. doi: 10.1097/MD.0000000000031280.
The study aims to provide a comprehensive account of the association between the epidermal growth factor (EGF) + 61A/G polymorphism (rs4444903) and susceptibility to virus-related hepatocellular carcinoma (HCC).
Electronic searching of the Chinese National Knowledge Infrastructure, Wanfang, Chinese Scientific Journal Database (VIP), PubMed, Web of Science, and Embase was conducted to select eligible studies. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to assess the strength of the association.
In this study, a total of 18 articles were included with 2692 cases and 5835 controls for assessing the association between rs4444903 and HCC risk. The pooled results showed that the EGF + 61A/G polymorphism was significantly associated with the risk of virus-related HCC in all genetic models. Stratified analyses were conducted based on ethnicity, study quality, source of controls, type of controls, number of cases and genotyping method. The results showed that EGF + 61A/G polymorphisms significantly affect HCC susceptibility in different stratified populations. High heterogeneity was observed across included studies, and meta-regression analysis demonstrated that race, type of controls, and study quality contribute to the observed heterogeneity.
This pooled analysis found that EGF + 61A/G polymorphism was significantly associated with the risk of HCC.
本研究旨在全面阐述表皮生长因子（EGF）+61A/G 多态性（rs4444903）与病毒相关性肝细胞癌（HCC）易感性之间的关联。
通过电子检索中国知网、万方、中国科学引文数据库（VIP）、PubMed、Web of Science 和 Embase，筛选出符合条件的研究。使用比值比（OR）和 95%置信区间（95%CI）评估关联的强度。
本研究共纳入 18 篇文章，共纳入 2692 例病例和 5835 例对照，评估 rs4444903 与 HCC 风险之间的关联。汇总结果表明，EGF+61A/G 多态性与所有遗传模型中的病毒相关性 HCC 风险显著相关。基于种族、研究质量、对照来源、对照类型、病例数量和基因分型方法进行了分层分析。结果表明，EGF+61A/G 多态性在不同分层人群中显著影响 HCC 的易感性。纳入研究存在高度异质性，荟萃回归分析表明，种族、对照类型和研究质量导致了观察到的异质性。
本荟萃分析发现 EGF+61A/G 多态性与 HCC 风险显著相关。
