Cook D G, Shaper A G, Thelle D S, Whitehead T P
Postgrad Med J. 1986 Nov;62(733):1001-6. doi: 10.1136/pgmj.62.733.1001.
The relationships between serum uric acid, serum glucose and diabetes have been examined in a survey of 7735 middle-aged men drawn at random from general practices in 24 British towns. There was a positive relationship between serum glucose and serum uric acid concentrations up to about 8.0 mmol/l; at higher levels of glucose, serum uric acid decreased. Uric acid levels were significantly reduced in insulin-dependent diabetics and in those on oral hypoglycaemics and also in 'non-diabetics' with casual glucose levels greater than 10 mmol/l. Both uric acid and glucose concentrations were positively related to body mass index; only uric acid was positively related to alcohol intake. Men on antihypertensive treatment had raised levels of uric acid (significant) and glucose (non-significant). The positive relationship between serum uric acid and serum glucose could not be explained by associations with body mass index, alcohol intake, age, social class, gout or treatment for hypertension. It probably reflects the biochemical interaction between serum glucose and purine metabolism, with increased excretion of uric acid during hyperglycaemia and glycosuria.
在一项对从英国24个城镇的普通诊所随机抽取的7735名中年男性进行的调查中，研究了血清尿酸、血糖与糖尿病之间的关系。血糖与血清尿酸浓度之间存在正相关关系，直至约8.0 mmol/l；在更高的血糖水平下，血清尿酸降低。胰岛素依赖型糖尿病患者、服用口服降糖药的患者以及随机血糖水平大于10 mmol/l的“非糖尿病患者”的尿酸水平显著降低。尿酸和血糖浓度均与体重指数呈正相关；只有尿酸与酒精摄入量呈正相关。接受抗高血压治疗的男性尿酸水平升高（显著），血糖水平升高（不显著）。血清尿酸与血糖之间的正相关关系无法用与体重指数、酒精摄入量、年龄、社会阶层、痛风或高血压治疗的关联来解释。这可能反映了血糖与嘌呤代谢之间的生化相互作用，高血糖症和糖尿症期间尿酸排泄增加。
