Appalachian Regional Healthcare, Harlan, KY, USA.
Appalachian Regional Healthcare, Whitesburg, KY, USA.
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221132244. doi: 10.1177/23247096221132244.
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare intracranial tumor that arises from pericytes surrounding the blood vessels. Solitary fibrous tumor/hemangiopericytoma accounts for less than 1% of primary brain tumors and is classified as grades I, II, or III based on mitotic count. These tumors often masquerade as meningiomas. Histologically, SFT/HPC is vascular with high cellularity and often surrounded by connective tissue. Immunohistochemistry is positive for stat 6, vimentin, and CD34. Although aggressive surgical resection is the mainstay of treatment, close long-term follow-up is necessary as recurrence or extra cranial metastasis can present several years after resection.
孤立性纤维瘤/血管外皮细胞瘤（SFT/HPC）是一种罕见的颅内肿瘤，起源于血管周围的周细胞。孤立性纤维瘤/血管外皮细胞瘤占原发性脑肿瘤的不到 1%，根据有丝分裂计数分为 I 级、II 级或 III 级。这些肿瘤常表现为脑膜瘤。组织学上，SFT/HPC 血管丰富，细胞密度高，常伴有结缔组织。免疫组化显示 stat6、波形蛋白和 CD34 阳性。虽然积极的手术切除是主要的治疗方法，但需要密切的长期随访，因为复发或颅外转移可能在切除后数年出现。
