Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Depress Anxiety. 2022 Dec;39(12):805-812. doi: 10.1002/da.23287. Epub 2022 Oct 25.
The purpose of this study was to investigate the psychiatric morbidity among men with abuse of anabolic steroids.
The design is a retrospectively matched cohort study. Five hundred and fourty-five males, who tested positive for anabolic steroids in Danish fitness centers during the period January 3, 2006 to March 1, 2018, were matched with 5450 randomly chosen male controls. Data was cross-referenced with seven national registers pertaining to information about education, employment status, and psychiatric comorbidity. Main outcomes and measures were prescription of psychopharmacological treatment.
The incidence of treatment with anxiolytics (HR: 2.34, 95% CI: 1.62-3.38) and antipsychotics (HR: 2.69, 95% CI: 1.99-3.63) displayed a remarkable increase in the years following doping sanction, compared to the control group. The prevalence of antidepressant use was already markedly elevated several years before doping sanction, but also displayed a higher incidence in the years following sanction (HR: 1.65, 95% CI: 1.28-2.13). The associations remained highly significant after controlling for socioeconomic factors.
Anabolic steroids use is strongly associated with psychiatric morbidity.
本研究旨在调查滥用合成代谢类固醇男性的精神疾病发病率。
该设计是一项回顾性匹配队列研究。2006 年 1 月 3 日至 2018 年 3 月 1 日期间，在丹麦健身中心检测出合成代谢类固醇呈阳性的 545 名男性与 5450 名随机选择的男性对照组相匹配。数据与七个国家登记册进行交叉参考，这些登记册涉及有关教育、就业状况和精神共病的信息。主要结局和措施是开具精神药理学治疗的处方。
与对照组相比，在兴奋剂制裁后的几年中，使用抗焦虑药（HR：2.34，95%CI：1.62-3.38）和抗精神病药（HR：2.69，95%CI：1.99-3.63）的治疗的发生率显著增加。在兴奋剂制裁前几年，抗抑郁药的使用已经明显升高，但在制裁后几年也显示出更高的发生率（HR：1.65，95%CI：1.28-2.13）。在控制社会经济因素后，这些关联仍然高度显著。
合成代谢类固醇的使用与精神疾病发病率密切相关。
Zotero 插件