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合成代谢雄激素类固醇与精神相关效应:综述

Anabolic-androgenic steroids and psychiatric-related effects: a review.

作者信息

Uzych L

出版信息

Can J Psychiatry. 1992 Feb;37(1):23-8. doi: 10.1177/070674379203700106.

DOI:10.1177/070674379203700106
PMID:1551042
Abstract

Anabolic-androgenic steroid use may have a wide range of adverse psychiatric and behavioural effects. The available data, however, are often inconsistent and inconclusive concerning possible effects of anabolic-androgenic steroids on libido in men, in women and also the way in which they affect libido differently in males and females. Anabolic-androgenic steroids may both relieve and cause depression. Cessation or diminished use of anabolic-androgenic steroids may also result in depression. More study is required to determine whether or not the disparate data on depression are consistent clinical observations. The level of testosterone appears to be positively associated with "aggression", particularly in response to provocation. Various psychotic symptoms and manic episodes may be associated with anabolic-androgenic steroids. The possibility of hypomania induced by synthetic androgens must also be considered.

摘要

使用合成代谢雄激素类固醇可能会产生广泛的不良精神和行为影响。然而,关于合成代谢雄激素类固醇对男性和女性性欲的可能影响,以及它们在男性和女性中对性欲产生不同影响的方式,现有数据往往不一致且无定论。合成代谢雄激素类固醇可能既能缓解抑郁,也能导致抑郁。停止使用或减少合成代谢雄激素类固醇的用量也可能导致抑郁。需要更多的研究来确定关于抑郁的不同数据是否为一致的临床观察结果。睾酮水平似乎与“攻击性”呈正相关,尤其是在受到挑衅时。各种精神病症状和躁狂发作可能与合成代谢雄激素类固醇有关。还必须考虑合成雄激素诱发轻躁狂的可能性。

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