Calocer Floriane, Ng Huah Shin, Zhu Feng, Zhao Yinshan, Dejardin Olivier, Leray Emmanuelle, Defer Gilles, Evans Charity, Fisk John D, Marrie Ruth Ann, Tremlett Helen
Department of Medicine, Division of Neurology and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, UBC Hospital, Vancouver, BC, Canada.
UNICAEN, CHU de Caen, INSERM U1086 ANTICIPE, Pôle de Recherche, Normandie University, Caen, France.
Mult Scler. 2023 Mar;29(3):466-470. doi: 10.1177/13524585221129963. Epub 2022 Oct 25.
The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood.
To investigate the association between SES and mortality risk in PwMS.
From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS 'onset') occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality.
Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36-1.91); SES-Q2 = 1.26 (95% CI = 1.05-1.50); SES-Q3 = 1.22 (95% CI = 1.02-1.46); SES-Q4 = 1.13 (95% CI = 0.94-1.35) versus SES-Q5 (least deprived).
A lower SES was associated with higher mortality risk in PwMS.
社会经济地位（SES）与多发性硬化症患者（PwMS）死亡率之间的关系尚不清楚。
研究PwMS中SES与死亡风险之间的关联。
从卫生行政数据中，我们识别出12126例1994年至2017年间首次发生脱髓鞘事件（MS“发病”）的新发MS病例。Cox比例风险模型评估了MS发病时社会经济地位五分位数（SES-Qs）与全因死亡率之间的关联。
较低的SES-Qs与较高的死亡风险相关；调整后的风险比：SES-Q1（最贫困）=1.61（95%置信区间（CI）=1.36-1.91）；SES-Q2=1.26（95%CI=1.05-1.50）；SES-Q3=1.2（95%CI=1.02-1.46）；SES-Q4=1.13（95%CI=0.94-1.35），而SES-Q5（最不贫困）。
较低的SES与PwMS较高的死亡风险相关。
