Hökfelt T, Schultzberg M, Elde R, Nilsson G, Terenius L, Said S, Goldstein M
Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:79-89. doi: 10.1111/j.1600-0773.1978.tb03224.x.
Using the indirect immunofluorescence technique of Coons and collaborators, neurons containing substance P-, enkephalin-, vasoactive intestinal polypeptide (VIP)--and somatostatin-like immuno-reactivity have been identified in the peripheral nervous system. They have a widespread distribution, particularly in the gastrointestinal and urinary tracts. Whereas part of these peptide containing fibres may belong to sensory neurons, the majority seem to have their origin in peripheral autonomic ganglia, indicating a complex built up of the autonomic nervous system. There is evidence that some noradrenergic neurons contain somatostatin, which may suggest that one neuron can synthesize and store two transmitters. The significance of such neurons, as well as of peripheral peptide neurons in general, remains to be elucidated.
运用孔斯及其同事的间接免疫荧光技术，已在外周神经系统中鉴定出含有P物质、脑啡肽、血管活性肠肽（VIP）和生长抑素样免疫反应性的神经元。它们分布广泛，尤其在胃肠道和泌尿道。虽然这些含肽纤维部分可能属于感觉神经元，但大多数似乎起源于外周自主神经节，这表明自主神经系统的构成很复杂。有证据表明，一些去甲肾上腺素能神经元含有生长抑素，这可能意味着一个神经元能够合成并储存两种递质。这类神经元以及外周肽能神经元的总体意义仍有待阐明。
