Andersson K E, Forman A
Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:90-5. doi: 10.1111/j.1600-0773.1978.tb03225.x.
A short review is given of the effects of prostaglandins on the smooth muscle of the bladder, urethra and ureter. In several animal species and in man, prostaglandins of the E and F types contract the detrusor. The contractions develop slowly and are not affected by tetrodotoxin, phenoxybenzamine, or atropine, suggesting a direct effect on the smooth muscle cell. However, evidence is also available suggesting a role of the prostaglandins as modulators of transmitter release in the bladder. In animals as well as in man, urethral smooth muscle is contracted by prostaglandin F2alpha, but relaxed by prostaglandins E1 and E2. The smooth muscle of the ureter seems to react similarly, but published results vary. The detailed mode of action, and the role of prostaglandins in the control of activity in urinary tract smooth muscle remain to be established.
本文简要综述了前列腺素对膀胱、尿道和输尿管平滑肌的作用。在多个动物物种及人类中，E型和F型前列腺素可使逼尿肌收缩。这种收缩发展缓慢，且不受河豚毒素、酚苄明或阿托品影响，提示其对平滑肌细胞有直接作用。然而，也有证据表明前列腺素在膀胱中作为递质释放的调节剂发挥作用。在动物和人类中，前列腺素F2α可使尿道平滑肌收缩，但前列腺素E1和E2则使其松弛。输尿管平滑肌的反应似乎类似，但已发表的结果存在差异。前列腺素在泌尿道平滑肌活动控制中的详细作用方式及角色仍有待确定。
