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刺激的θ模式可诱导 O-LM 中间神经元的突触和内在增强。

Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons.

机构信息

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS), UMR1072, INSERM, Aix-Marseille University, Marseille, 13015, France.

出版信息

Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2205264119. doi: 10.1073/pnas.2205264119. Epub 2022 Oct 25.

DOI:10.1073/pnas.2205264119
PMID:36282913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9636972/
Abstract

Brain oscillations have long-lasting effects on synaptic and cellular properties. For instance, synaptic stimulation at theta (θ) frequency induces persistent depression of both excitatory synaptic transmission and intrinsic excitability in CA1 principal neurons. However, the incidence of θ activity on synaptic transmission and intrinsic excitability in hippocampal GABAergic interneurons is unclear. We report here the induction of both synaptic and intrinsic potentiation in oriens-lacunosum moleculare (O-LM) interneurons following stimulation of afferent glutamatergic inputs in the θ frequency range (∼5 Hz). Long-term synaptic potentiation (LTP) is induced by synaptic activation of calcium-permeable AMPA receptors (CP-AMPAR), whereas long-term potentiation of intrinsic excitability (LTP-IE) results from the mGluR1-dependent down-regulation of Kv7 voltage-dependent potassium channel and hyperpolarization activated and cyclic nucleotide-gated (HCN) channel through the depletion of phosphatidylinositol-4,5-biphosphate (PIP2). LTP and LTP-IE are reversible, demonstrating that both synaptic and intrinsic changes are bidirectional in O-LM cells. We conclude that synaptic activity at θ frequency induces both synaptic and intrinsic potentiation in O-LM interneurons, i.e., the opposite of what is typically seen in glutamatergic neurons.

摘要

脑振荡对突触和细胞特性具有持久的影响。例如，在θ（θ）频率下进行突触刺激会导致 CA1 主神经元的兴奋性突触传递和固有兴奋性持续抑制。然而，θ 活动对海马 GABA 能中间神经元的突触传递和固有兴奋性的影响尚不清楚。我们在这里报告，在θ频率范围内（约 5 Hz）刺激传入谷氨酸能输入后，在齿状回分子层（O-LM）中间神经元中诱导了突触和固有增强。长时程突触增强（LTP）是通过钙通透性 AMPA 受体（CP-AMPAR）的突触激活诱导的，而固有兴奋性的长时程增强（LTP-IE）则是由于 mGluR1 依赖性 Kv7 电压依赖性钾通道和超极化激活和环核苷酸门控（HCN）通道的下调，通过耗尽磷脂酰肌醇-4,5-二磷酸（PIP2）而导致的。LTP 和 LTP-IE 是可逆的，表明 O-LM 细胞中的突触和固有变化都是双向的。我们得出结论，θ 频率的突触活动在 O-LM 中间神经元中诱导了突触和固有增强，即与谷氨酸能神经元中通常看到的相反。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/0946aea53fa5/pnas.2205264119fig07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/3da34a8ab5d5/pnas.2205264119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/9f38f56c3e66/pnas.2205264119fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/c70c82867c95/pnas.2205264119fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/2f3f5cf995a6/pnas.2205264119fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/9cfecf1a6fbc/pnas.2205264119fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/48accfd7c0de/pnas.2205264119fig06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/0946aea53fa5/pnas.2205264119fig07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/3da34a8ab5d5/pnas.2205264119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/9f38f56c3e66/pnas.2205264119fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/c70c82867c95/pnas.2205264119fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/2f3f5cf995a6/pnas.2205264119fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/9cfecf1a6fbc/pnas.2205264119fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/48accfd7c0de/pnas.2205264119fig06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b4/9636972/0946aea53fa5/pnas.2205264119fig07.jpg

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[2]
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[5]
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[6]
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[10]
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本文引用的文献

[1]
Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit.

Proc Natl Acad Sci U S A. 2021-11-23

[2]
mGlu potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits.

Cell Rep. 2021-11-2

[3]
Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels.

J Neurosci. 2021-11-17

[4]
Synaptic plasticity rules with physiological calcium levels.

Proc Natl Acad Sci U S A. 2020-12-29

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Nicotinic receptor activation induces NMDA receptor independent long-term potentiation of glutamatergic signalling in hippocampal oriens interneurons.

J Physiol. 2021-1

[6]
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output.

Nat Commun. 2020-9-2

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Theta Oscillations Coincide with Sustained Hyperpolarization in CA3 Pyramidal Cells, Underlying Decreased Firing.

Cell Rep. 2020-7-7

[8]
Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells.

Elife. 2020-6-4

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Hippocampus. 2019-7-13

[10]
Plasticity of intrinsic neuronal excitability.

Curr Opin Neurobiol. 2018-9-19

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