Rankin-Turner Stephanie, Heaney Liam M
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Clin Chem Lab Med. 2022 Oct 26;61(5):873-879. doi: 10.1515/cclm-2022-0984. Print 2023 Apr 25.
Mass spectrometry (MS) has been a gold standard in the clinical laboratory for decades. Although historically refined to limited areas of study such as neonatal screening and steroid analysis, technological advancements in the field have resulted in MS becoming more powerful, versatile, and user-friendly than ever before. As such, the potential for the technique in clinical chemistry has exploded. The past two decades have seen advancements in biomarker detection for disease diagnostics, new methods for protein measurement, improved methodologies for reliable therapeutic drug monitoring, and novel technologies for automation and high throughput. Throughout this time, has embraced the rapidly developing field of mass spectrometry, endeavoring to highlight the latest techniques and applications that have the potential to revolutionize clinical testing. This mini review will highlight a selection of these critical contributions to the field.
几十年来，质谱分析法（MS）一直是临床实验室的金标准。尽管从历史上看，它主要应用于新生儿筛查和类固醇分析等有限的研究领域，但该领域的技术进步使质谱分析法比以往任何时候都更强大、更通用且更便于用户使用。因此，该技术在临床化学中的潜力得到了极大的发挥。在过去二十年中，疾病诊断的生物标志物检测取得了进展，蛋白质测量出现了新方法，可靠的治疗药物监测方法得到了改进，自动化和高通量的新技术也不断涌现。在此期间，[具体内容缺失]一直紧跟快速发展的质谱分析领域，致力于突出那些有可能彻底改变临床检测的最新技术和应用。本综述将重点介绍该领域的一系列关键贡献。
