Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA; Department of Biology, New York University, 100 Washington Square East, 1009 Silver Center, New York, NY 10003, USA.
Department of Mathematics, University of California, Irvine, 419 Rowland Hall, Irvine, CA 92697, USA.
Curr Biol. 2022 Oct 24;32(20):R1033-R1035. doi: 10.1016/j.cub.2022.09.025.
Actin networks adapt to resistance by becoming denser. A recent investigation shows that this mechanosensation relies on a force-sensitive mechanical ratchet of capping actin filaments to reorganize the network. This and other mechanical feedback mechanisms make actin-based protrusion amazingly robust.
肌动蛋白网络通过变得更加密集来适应抵抗。最近的一项研究表明,这种机械感觉依赖于一种对力敏感的肌动蛋白丝加帽机械棘轮,以重新组织网络。这种和其他机械反馈机制使基于肌动蛋白的突起具有惊人的鲁棒性。