Halberg J, Halberg E, Halberg F, Munson E
Prog Clin Biol Res. 1987;227B:315-22.
A circadian rhythm in anesthetic index is quantified by the single cosinor method in data published earlier. Although the double circadian amplitude, a measure of the extent of predictable change, is only 14%, the assumption of no rhythm (zero amplitude) is rejected at the 1% level of statistical significance. It seems likely that, in the absence of noise, the amplitude of the rhythmic change in the response to the anesthetic will be larger. The broader importance of chronobiology for anesthesiologists is also indicated. Hardware and software for the monitoring of a patient's vital signs before, during, and after surgery provide refined dynamic endpoints from the analysis of data series and lead to time-specified reference values that improve even the interpretation of time-specified single values.
在先前发表的数据中，采用单一余弦分析法对麻醉指数的昼夜节律进行了量化。虽然可预测变化程度的双昼夜振幅仅为14%，但无节律（零振幅）的假设在1%的统计学显著性水平上被拒绝。在无噪声的情况下，麻醉反应的节律性变化幅度可能会更大。这也表明了时间生物学对麻醉医生更广泛的重要性。用于监测患者手术前、手术中和手术后生命体征的硬件和软件，通过对数据系列的分析提供了精确的动态终点，并得出特定时间的参考值，甚至能改善对特定时间单一值的解读。
