Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
B.N.Patel Institute of Paramedical & Science (Science Division), Sardar Patel Education Trust, Bhalej Road, Anand 388001, Gujarat, India.
Int J Biol Macromol. 2023 Jan 1;224:358-369. doi: 10.1016/j.ijbiomac.2022.10.129. Epub 2022 Oct 22.
The aim of this study was to better understand the underlying drug release characteristics from Gg-cl-poly(NIPA-co-AA)/CoFe2O4 hydrogel containing metformin hydrochloride as model drug. Nanocomposite's hydrogel of gum ghatti free radical polymerization is used for the controlled release of metformin hydrogen chloride. Gum ghatti and CoFe2O4 nanoparticle dispersion were grafted by acrylic acid and N-isopropylacrylamide, employing graft copolymerization in the presence of N, N'-methylene-bis-acrylamide (MBA) as cross linker, and ammonium persulfate (APS) as initiator. The synthesized nanocomposites hydrogel was characterized using FTIR, SEM, TGA and DSC. Drugs were all released through diffusion in the hydrated matrix and polymer relaxation, irrespective of the drug solubility. In vitro drug release studies, at different pH values of pH = 4.0, 7.4 and 9.2 was employed. Drug release was influenced by the change of pH. The pH of 7.4 was considered as the optimized pH for maximum drug release. The nanocomposites hydrogel was loaded with metformin hydrochloride drug (100 mg) which is an antidiabetic drug to investigate the release profiles in PBS (pH 7.4). The effects of polymer level and initial drug loading on release depended on drug properties. Different models were studied for release kinetic studies which showed that the zero-order model suggested the best kinetics release studies in PBS (pH- 7.4) and showed sustained release. The kinetics of drug release were discovered to fit the Korsmeyer-Peppas model with n > 1, indicating a specific case II transport mechanism.
本研究旨在更好地了解载盐酸二甲双胍的 Gg-cl-poly(NIPA-co-AA)/CoFe2O4 水凝胶的药物释放特性。纳米复合水凝胶是通过 Gum Ghatti 自由基聚合，以控制盐酸二甲双胍的释放。将 Gum Ghatti 和 CoFe2O4 纳米颗粒分散体接枝到丙烯酸和 N-异丙基丙烯酰胺上，在 N，N'-亚甲基双丙烯酰胺（MBA）作为交联剂和过硫酸铵（APS）作为引发剂存在的情况下进行接枝共聚。使用傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、热重分析（TGA）和差示扫描量热法（DSC）对合成的纳米复合材料水凝胶进行了表征。所有药物都是通过扩散在水合基质和聚合物松弛中释放的，而与药物的溶解度无关。在不同的 pH 值（pH=4.0、7.4 和 9.2）下进行了体外药物释放研究。药物释放受 pH 值变化的影响。考虑到 pH 值为 7.4 时可以达到最大药物释放的优化 pH 值。该纳米复合材料水凝胶载有盐酸二甲双胍药物（100mg），这是一种抗糖尿病药物，用于研究在 PBS（pH=7.4）中的释放曲线。聚合物水平和初始药物载量对释放的影响取决于药物性质。研究了不同的模型来进行释放动力学研究，结果表明零级模型在 PBS（pH-7.4）中提出了最佳的动力学释放研究，并表现出持续释放。药物释放动力学被发现符合 Korsmeyer-Peppas 模型，n＞1，表明存在特定的 II 型转运机制。
