Department of Chemistry, University College, Mangalore University, Mangalore 575001, Karnataka, India.
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Int J Biol Macromol. 2023 Dec 31;253(Pt 3):126882. doi: 10.1016/j.ijbiomac.2023.126882. Epub 2023 Sep 16.
An interpenetrating polymer network (IPN) of areca cellulose and guar gum grafted with poly (N, N'-dimethylacrylamide) was made by microwave irradiation technique. N, N-methylenebisacrylamide (MBA) was used as the crosslinking agent. The network polymer was characterised using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Powder X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM). The chemical interaction between the drug and the polymer was studied using Differential Scanning Calorimetry (DSC). The swelling of the gel was measured under different pH conditions and the swelling parameters were evaluated. The gel was loaded with an anti-diabetic drug, Metformin Hydrochloride, and the in vitro drug release was studied in gastric and intestinal conditions. The results indicated complete release of the drug in 6 h under pH 1.2 and in 10 h under pH 7.4. The kinetic analysis of release data indicated the drug release to follow Higuchi's model. The release exponent "n" of Korsmeyer-Peppas model was found to be >0.45 indicating the drug diffusion to be a non-Fickian process.
采用微波辐射技术制备了具有聚（N，N'-二甲基丙烯酰胺）接枝的槟榔纤维素和瓜尔胶互穿聚合物网络（IPN）。N，N'-亚甲基双丙烯酰胺（MBA）用作交联剂。使用傅里叶变换红外光谱（FTIR）、热重分析（TGA）、粉末 X 射线衍射（XRD）和场发射扫描电子显微镜（FESEM）对网络聚合物进行了表征。使用差示扫描量热法（DSC）研究了药物与聚合物之间的化学相互作用。在不同 pH 条件下测量了凝胶的溶胀，并评估了溶胀参数。将凝胶负载抗糖尿病药物盐酸二甲双胍，并在胃和肠条件下研究了体外药物释放。结果表明，在 pH 1.2 下 6 小时内药物完全释放，在 pH 7.4 下 10 小时内药物完全释放。释放数据的动力学分析表明，药物释放遵循 Higuchi 模型。Korsmeyer-Peppas 模型的释放指数“n”大于 0.45，表明药物扩散是非菲克过程。
