Wang Yuhan, Zhang Humin, Li Huang, Xiong Jie, Wang Jie, Huang Yuanshuai
Department of Transfusion, Yaan People's Hospital, Ya'an, 625000, China.
Department of Clinical Medicine, Southwest Medical University, Luzhou, 646000, China.
Clin Transl Oncol. 2023 Jan;25(1):114-125. doi: 10.1007/s12094-022-02937-1. Epub 2022 Oct 25.
The incidence of malignant tumors is increasing year by year. Early detection and diagnosis of malignant tumors can improve the prognosis of patients and prolong their life. Pathological biopsy is the current gold standard for diagnosis, but the results of pathological biopsy are affected by the sampling site and cannot fully reflect the nature of the disease. Moreover, the invasive nature of pathological biopsy limits repeated detection. Liquid biopsies are non-invasive and can be used for early detection and monitoring of tumors, which considered to represent a promising tool. Platelets make themselves to be one of the richest liquid biopsy sources by the capacity to take up proteins and nucleic acids and alter their megakaryocyte-derived transcripts and proteins in response to external signals, which are called tumor-educated platelets (TEPs). In this article, we will review the application of tumor-educated platelets in various malignancies (nasopharyngeal carcinoma, prostate cancer, lung cancer, glioblastoma, colorectal cancer, pancreas cancer, ovarian cancer, sarcoma, breast cancer and hepatocellular carcinoma) and provide theoretical basis for the research of TEPs in tumor diagnosis, monitoring and treatment.
恶性肿瘤的发病率逐年上升。早期发现和诊断恶性肿瘤可改善患者预后并延长其寿命。病理活检是目前的诊断金标准，但病理活检结果受取样部位影响，无法完全反映疾病本质。此外，病理活检的侵入性限制了重复检测。液体活检是非侵入性的，可用于肿瘤的早期检测和监测，被认为是一种有前景的工具。血小板通过摄取蛋白质和核酸并响应外部信号改变其巨核细胞衍生的转录本和蛋白质的能力，使其成为最丰富的液体活检来源之一，这些被称为肿瘤驯化血小板（TEP）。在本文中，我们将综述肿瘤驯化血小板在各种恶性肿瘤（鼻咽癌、前列腺癌、肺癌、胶质母细胞瘤、结直肠癌、胰腺癌、卵巢癌、肉瘤、乳腺癌和肝细胞癌）中的应用，并为肿瘤驯化血小板在肿瘤诊断、监测和治疗方面的研究提供理论依据。
