Figols Mariona, Chekhun Sviatoslav, Fernández-Saorin Maria, Pérez-Criado Ignacio, Bautista Ana, Font Albert, Ruiz de Porras Vicenç
Medical Oncology Department, Althaia Xarxa Assistencial Universitària de Manresa, C/ Dr. Joan Soler, 1-3, 08243 Manresa, Spain.
PhD Programme in Medicine and Biomedical Sciences, Doctoral School, University of Vic, Central University of Catalonia (UVic-UCC), C/ Dr. Junyent, 1, 08500 Vic, Spain.
Int J Mol Sci. 2025 Apr 11;26(8):3595. doi: 10.3390/ijms26083595.
Platelets, traditionally recognized for their role in hemostasis, have emerged as pivotal players in cancer biology. They actively contribute to tumor proliferation, angiogenesis, immune evasion, and metastasis and thus play a significant role in cancer progression. Tumor-educated platelets (TEPs) acquire protumorigenic phenotypes through RNA, protein, and receptor profile alterations driven by interactions with tumors and their microenvironment. These modifications enable TEPs to enhance tumor growth and dissemination and to play a critical role throughout the metastatic process. Moreover, TEPs are promising biomarkers that can easily be analyzed in liquid biopsies. Since they dynamically mirror tumor activity through transcriptomic and proteomic changes, their analysis offers a non-invasive method for determining cancer detection and diagnosis, patient prognosis, therapy monitoring, and personalization of treatment. Their demonstrated accuracy in identifying cancer types and predicting treatment responses underscores their ability to provide real-time insights into tumor biology, including in urological malignancies. Their diagnostic potential and their accessibility as blood-sourced biomarkers position TEPs as transformative tools in advancing personalized oncology. Here, we focus on the role of TEPs in urological tumors, exploring their applications in early cancer detection, disease monitoring, and the design of tailored therapeutic strategies.
血小板，传统上因其在止血中的作用而被认可，如今已成为癌症生物学中的关键角色。它们积极促进肿瘤增殖、血管生成、免疫逃逸和转移，因此在癌症进展中发挥着重要作用。肿瘤驯化血小板（TEPs）通过与肿瘤及其微环境相互作用驱动的RNA、蛋白质和受体谱改变获得促肿瘤表型。这些修饰使TEPs能够促进肿瘤生长和扩散，并在整个转移过程中发挥关键作用。此外，TEPs是很有前景的生物标志物，可在液体活检中轻松分析。由于它们通过转录组和蛋白质组变化动态反映肿瘤活性，对其分析提供了一种用于确定癌症检测与诊断、患者预后、治疗监测和治疗个性化的非侵入性方法。它们在识别癌症类型和预测治疗反应方面已证实的准确性突出了其提供肿瘤生物学实时见解的能力，包括在泌尿生殖系统恶性肿瘤中。它们作为血液来源生物标志物的诊断潜力和可及性使TEPs成为推进个性化肿瘤学的变革性工具。在此，我们聚焦于TEPs在泌尿生殖系统肿瘤中的作用，探索它们在早期癌症检测、疾病监测以及定制治疗策略设计中的应用。
