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基于黏附与摩擦耦合的骨整合种植体脱粘过程建模。

Modeling the debonding process of osseointegrated implants due to coupled adhesion and friction.

机构信息

Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, Templergraben 55, 52056, Aachen, Germany.

MSME, CNRS UMR 8208, Université Paris-Est Créteil, Université Gustave Eiffel, 94010, Créteil, France.

出版信息

Biomech Model Mechanobiol. 2023 Feb;22(1):133-158. doi: 10.1007/s10237-022-01637-7. Epub 2022 Oct 25.

DOI:10.1007/s10237-022-01637-7
PMID:36284076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9957925/
Abstract

Cementless implants have become widely used for total hip replacement surgery. The long-term stability of these implants is achieved by bone growing around and into the rough surface of the implant, a process called osseointegration. However, debonding of the bone-implant interface can still occur due to aseptic implant loosening and insufficient osseointegration, which may have dramatic consequences. The aim of this work is to describe a new 3D finite element frictional contact formulation for the debonding of partially osseointegrated implants. The contact model is based on a modified Coulomb friction law by Immel et al. (2020), that takes into account the tangential debonding of the bone-implant interface. This model is extended in the direction normal to the bone-implant interface by considering a cohesive zone model, to account for adhesion phenomena in the normal direction and for adhesive friction of partially bonded interfaces. The model is applied to simulate the debonding of an acetabular cup implant. The influence of partial osseointegration and adhesive effects on the long-term stability of the implant is assessed. The influence of different patient- and implant-specific parameters such as the friction coefficient [Formula: see text], the trabecular Young's modulus [Formula: see text], and the interference fit [Formula: see text] is also analyzed, in order to determine the optimal stability for different configurations. Furthermore, this work provides guidelines for future experimental and computational studies that are necessary for further parameter calibration.

摘要

无骨植入物已广泛应用于全髋关节置换手术。这些植入物的长期稳定性是通过骨骼在植入物的粗糙表面周围和内部生长来实现的，这个过程称为骨整合。然而，由于无菌性植入物松动和骨整合不足，仍然可能发生骨-植入物界面脱粘，这可能会产生重大影响。本工作的目的是描述一种新的用于部分骨整合植入物脱粘的三维有限元摩擦接触公式。接触模型基于 Immel 等人（2020 年）提出的修正库仑摩擦定律，考虑了骨-植入物界面的切向脱粘。通过考虑沿骨-植入物界面的粘聚区模型，该模型在垂直于骨-植入物界面的方向上得到扩展，以考虑正常方向的粘附现象和部分粘结界面的粘着摩擦。该模型应用于模拟髋臼杯植入物的脱粘。评估了部分骨整合和粘弹性对植入物长期稳定性的影响。分析了不同患者和植入物特定参数（如摩擦系数 [Formula: see text]、小梁杨氏模量 [Formula: see text]和过盈配合 [Formula: see text]）的影响，以确定不同配置的最佳稳定性。此外，这项工作为进一步的实验和计算研究提供了指导，这些研究对于进一步的参数校准是必要的。

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Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena.定量超声评估粗糙度和愈合时间对骨整合现象的影响。
Sci Rep. 2020 Dec 15;10(1):21962. doi: 10.1038/s41598-020-78806-0.
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Multimodal characterization of the bone-implant interface using Raman spectroscopy and nanoindentation.
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Biomimetics (Basel). 2023 Oct 7;8(6):477. doi: 10.3390/biomimetics8060477.
采用拉曼光谱和纳米压痕技术对骨-植入物界面进行多模态表征。
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Multimodal Evaluation of the Spatiotemporal Variations of Periprosthetic Bone Properties.多模态评估人工关节周围骨特性的时空变化。
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