University of Chinese Academy of Sciences, Beijing, China.
Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Cell Death Dis. 2022 Oct 25;13(10):897. doi: 10.1038/s41419-022-05351-1.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from tumour cells reduce the efficacy of conventional cancer treatment paradigms and contribute to tumour progression and metastasis. As abundant tumour-promoting cells in the ECM, cancer-associated fibroblasts (CAFs) are promising targets for novel anti-tumour interventions. Nonetheless, related clinical trials are hampered by the lack of specific markers and elusive differences between CAF subtypes. Here, we review the origins and functional diversity of CAFs and show how they create a tumour-promoting milieu, focusing on the crosstalk between CAFs, tumour cells, and immune cells in the tumour microenvironment. Furthermore, relevant clinical advances and potential therapeutic strategies relating to CAFs are discussed.
胰腺导管腺癌 (PDAC) 是一种致命的癌症，其特点是细胞外基质 (ECM) 大量沉积，预后不良。源自肿瘤细胞的高水平 ECM 蛋白会降低传统癌症治疗模式的疗效，并促进肿瘤的进展和转移。成纤维细胞是 ECM 中丰富的促肿瘤细胞，是新型抗肿瘤干预措施的有前途的靶点。尽管如此，相关的临床试验还是受到缺乏特异性标志物和 CAF 亚型之间难以捉摸的差异的阻碍。在这里，我们回顾了 CAF 的起源和功能多样性，并展示了它们如何创造一个促进肿瘤生长的环境，重点讨论了肿瘤微环境中 CAF、肿瘤细胞和免疫细胞之间的串扰。此外，还讨论了与 CAF 相关的相关临床进展和潜在的治疗策略。
