Zhou Quan, Li Gordon
Departments of Neurosurgery and.
Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, California.
Neurosurg Focus Video. 2022 Jan 1;6(1):V9. doi: 10.3171/2021.10.FOCVID21201. eCollection 2022 Jan.
A contrast-enhancing lesion in the left temporal lobe of a 72-year-old woman was biopsied and diagnosed as glioblastoma. Near-infrared (NIR)-labeled epidermal growth factor receptor (EGFR) antibody, panitumumab-IRDye800, was infused 52 hours before craniotomy without pretreatment. Tumor fluorescence was detected through intact dura, and the visual contrast between disease and peritumoral healthy brain was enhanced after tumor exposure. Residual cancerous tissue was identified with strong fluorescence in resection cavity after en bloc tumor removal. Minimal fluorescence remained in the final wound bed, likely from nonenhancing tumor. Fluorescence was heterogeneously distributed at the infiltrative margin in resected tumor pieces imaged ex vivo. Postoperative MRI confirmed gross-total resection. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21201.
对一名72岁女性左颞叶的一个强化病变进行活检，诊断为胶质母细胞瘤。在未进行预处理的情况下，于开颅手术前52小时注入近红外（NIR）标记的表皮生长因子受体（EGFR）抗体帕尼单抗 - IRDye800。通过完整的硬脑膜检测到肿瘤荧光，肿瘤暴露后，病变与瘤周健康脑之间的视觉对比度增强。在整块切除肿瘤后，在切除腔内发现残留癌组织有强烈荧光。最终伤口床中残留的荧光极少，可能来自无强化的肿瘤。荧光在离体成像的切除肿瘤块的浸润边缘呈异质性分布。术后磁共振成像（MRI）证实为大体全切。视频可在此处查看：https://stream.cadmore.media/r10.3171/2021.10.FOCVID21201
