Badla Omar, Goit Raman, Saddik Samia E, Dawood Sarah, Rabih Ahmad M, Mohammed Ahmad, Raman Aishwarya, Uprety Manish, Calero Maria, Villanueva Maria Resah B, Joshaghani Narges, Villa Nicole, Mohammed Lubna
General Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2022 Sep 20;14(9):e29347. doi: 10.7759/cureus.29347. eCollection 2022 Sep.
Perianal fistulas in Crohn's disease (CD) are often recurring and challenging to treat. This systematic review aimed to evaluate the medical, surgical, and combination treatment options and provide an overview of their efficacy. We performed this systematic review following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Our group searched PubMed, Medline, PubMed Central, Google Scholar, and ScienceDirect for articles within the last ten years using different terms and criteria mentioned in detail in the search strategy and eligibility criteria sections. Initially, 739 records were retrieved, out of which we excluded 731 records for various reasons, such as irrelevant titles and abstracts and low scores on quality assessment tools. The evidence for combination (surgical and medical) therapy is superior to that for medical and surgical treatments individually. In contrast, the studies on medical and surgical treatments individually reported varied evidence and efficacy for their respective options.
克罗恩病（CD）中的肛周瘘管常常复发且治疗颇具挑战性。本系统评价旨在评估药物、手术及联合治疗方案，并概述其疗效。我们按照系统评价和Meta分析的首选报告项目（PRISMA）指南进行了本系统评价。我们的团队在过去十年内，使用检索策略和纳入标准部分详细提及的不同术语和标准，在PubMed、Medline、PubMed Central、谷歌学术和ScienceDirect中搜索文章。最初检索到739条记录，出于各种原因，我们排除了731条记录，如标题和摘要不相关以及质量评估工具得分较低。联合（手术和药物）治疗的证据优于单独的药物和手术治疗。相比之下，关于单独药物和手术治疗的研究各自报告了不同的证据和疗效。
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