Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Pakistan.
Arch Razi Inst. 2022 Apr 30;77(2):525-536. doi: 10.22092/ARI.2021.356279.1816. eCollection 2022 Apr.
Increasing pieces of evidence have supported those chemicals from industrial, agricultural wastes and organoleptic activities play important role in the development of neurological disorders. The frequency of neurological disorders is increased to a much extent in recent years with the advancements in science and technology. Google Scholar, PubMed, and Scopus databases were selected to search the relevant information by using keywords including "Heavy metals", "Neurotoxicity", "Glutathione", "Glutathione AND Neurodegenerative disorders" etc. Heavy metals are particularly recognized as a major resource of toxicities during the stage of early pregnancy where a fetus gets exposed to them from maternal activities and circulation. As infants have a weak immune system and cannot respond to the specific challenge as faced by the body during mercury, zinc, iron, and cadmium exposure. Daily diet and drinking habits in addition to industrial activities also form a major field of study under investigation. This study aims to investigate the role of these metals in the accumulation of pollutants in the brain, liver, and kidneys hence leading to serious consequences. Moreover, their prevalence in teenagers that are under the age of ten years is being observed that leads them to learn, writing, and intellectual abilities. Males are more affected due to their hormonal differences. The role of the GST gene in the development of cognitive conditions and its phenotypes has been discussed thoroughly in this review. The mutations of GST lead to the accumulation of peroxides and superoxides which exacerbate oxidative damage to cells. Binding of toxic metals to GSH genes and the role of glutathione transferase genes is was demonstrated in this review.
越来越多的证据表明，工业、农业废物和感官活动中的化学物质在神经紊乱的发展中起着重要作用。近年来，随着科学技术的进步，神经紊乱的发病率大大增加。通过使用包括“重金属”、“神经毒性”、“谷胱甘肽”、“谷胱甘肽和神经退行性疾病”等关键词，从谷歌学术、PubMed 和 Scopus 数据库中选择了相关信息进行搜索。重金属在妊娠早期阶段被特别认为是毒性的主要来源，因为胎儿会从母体活动和循环中接触到这些物质。由于婴儿的免疫系统较弱，无法像身体在汞、锌、铁和镉暴露时那样对特定的挑战做出反应。日常饮食和饮食习惯以及工业活动也是研究的主要领域。本研究旨在探讨这些金属在大脑、肝脏和肾脏中污染物积累中的作用，从而导致严重后果。此外，还观察到 10 岁以下青少年的流行率，这导致他们在学习、写作和智力能力方面受到影响。由于激素差异，男性受影响更大。本综述深入讨论了 GST 基因在认知状况及其表型发展中的作用。GST 的突变导致过氧化物和超氧化物的积累，从而加剧细胞的氧化损伤。本综述还展示了有毒金属与 GSH 基因的结合以及谷胱甘肽转移酶基因的作用。
