Calcitonin effect on the dipsogenic response to intra-cerebroventricular administration of angiotensin II.

Evidence indicates that intra-third cerebroventricular (III-ICV) administration of calcitonin suppresses food and water intake of rats. The purpose of this study was to determine whether calcitonin would influence angiotensin II-induced dipsogenesis when simultaneously administered III-ICV. Administration of calcitonin (0.5 U/rat) suppressed food and water intake in male Wistar rats. III-ICV administration of angiotensin II (100 ng/rat) to rats provided with ad lib food and water elicited short latency drinking without affecting food intake. III-ICV administration of calcitonin (0.5 U/rat) did not affect the drinking-inducing response to 100 ng/rat of angiotensin II when administered simultaneously. The results suggest that decrease in water intake by III-ICV calcitonin may be a consequence of the food intake suppression, i.e., reduced prandial drinking.