Chronic infusion of angiotensin II into the olfactory bulb elicits an increase in water intake.

Chronic infusion of angiotensin II (ANG II) into the olfactory bulb (OB) elicited a moderate dipsogenesis which occurred only during the dark phase, essentially doubling the water-to-food intake ratio. Removal of the food from the ANG II-OB group reduced water consumption to the level of the saline-infused/food-deprived controls. These experiments suggest that ANG II may interact with the OB to alter the normal water/food relationship.