在有机光氧化还原催化条件下烯酰胺的发散氰基烷基化/氰基烷基磺酰化反应。
Divergent cyanoalkylation/cyanoalkylsulfonylation of enamides under organophotoredox catalytic conditions.
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad-500007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
出版信息
Org Biomol Chem. 2022 Nov 16;20(44):8599-8604. doi: 10.1039/d2ob01775j.
An organophotoredox-catalyzed divergent cyanoalkylation/cyanoalkylsulfonylation of enamides in a highly regio- and stereoselective manner has been reported. In this mild and efficient protocol, cyclobutanone oxime esters serve as a cyanoalkylating source and inexpensive KSO serves as an SO surrogate. Broad substrate scope, compatibility of various sensitive functional groups and further functional group transformation are the highlights of this method.
本文报道了一种通过有机光氧化还原催化，以高区域和立体选择性的方式实现酰胺的氰基烷基化/氰基烷基亚磺化的反应。在这个温和高效的反应条件中，环丁酮肟酯作为氰烷基化试剂，廉价的 KSO 作为 SO 源。该方法具有广泛的底物适用性、对各种敏感官能团的兼容性以及进一步的官能团转化等特点，是该方法的亮点。
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