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药物治疗在痴呆伴发谵妄的管理中是否有作用?

Is There a Role for Medication in Managing Delirium with Dementia?

作者信息

Sampson Elizabeth L, Graham Frederick, Teodorczuk Andrew

机构信息

Department of Psychological Medicine, East London NHS Foundation Trust-Royal London Hospital, London E1 1BU, UK.

Division of Psychiatry, University College London, London W1T 7NF, UK.

出版信息

Geriatrics (Basel). 2022 Oct 7;7(5):114. doi: 10.3390/geriatrics7050114.

Abstract

People with dementia are more likely to develop delirium. We conducted a brief literature search and give a pragmatic overview of the key issues. Making rational and safe prescribing decisions is highly influenced by organisational culture and embedded staff practices. Comprehensive assessment for unmet physical, psychological, and social needs is an important intervention in itself. Taking a broad overview of possible pharmacological interventions should include stopping inappropriate medications and prescribing for key drivers of the underlying causes of delirium. Prescribing psychotropic medications may be indicated where there is significant distress or risk to the person with dementia and risk to those around them. It is vital to consider the dementia subtype and, where possible, involve family and friend carers in the decision-making process. Medications should be prescribed at the lowest possible dose for the least amount of time after carefully weighing risks versus benefits and documenting these. While these cases are challenging for staff and families, it can be rewarding to improve the quality of life and lessen distress for the person with dementia. There are also opportunities for informing family and friend carers, educating the wider multidisciplinary team, and promoting organisational change.

摘要

患有痴呆症的人更有可能出现谵妄。我们进行了一次简短的文献检索,并对关键问题进行了务实的概述。做出合理且安全的处方决策受到组织文化和固有员工行为的高度影响。对未满足的身体、心理和社会需求进行全面评估本身就是一项重要的干预措施。对可能的药物干预进行全面概述应包括停用不适当的药物,并针对谵妄潜在病因的关键驱动因素进行处方。在患有痴呆症的人存在严重痛苦或对其自身及周围人构成风险的情况下,可能需要开具精神药物。考虑痴呆症亚型并尽可能让家庭和朋友照顾者参与决策过程至关重要。在仔细权衡风险与益处并记录这些情况后,应以尽可能低的剂量、在最短的时间内开药。虽然这些情况对工作人员和家庭来说具有挑战性,但改善痴呆症患者的生活质量并减轻其痛苦可能会带来回报。此外,还有机会为家庭和朋友照顾者提供信息,教育更广泛的多学科团队,并推动组织变革。

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