幽门螺杆菌的惊人遗传学。
The Remarkable Genetics of Helicobacter pylori.
机构信息
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
出版信息
mBio. 2022 Dec 20;13(6):e0215822. doi: 10.1128/mbio.02158-22. Epub 2022 Oct 26.
The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent "free recombination" within populations. A recent article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:e01811-22, 2022, https://doi.org/10.1128/mbio.01811-22) helps to elucidate the cellular machinery that is used to achieve these unusual rates of genetic exchange. Specifically, they show that the UvrC gene, which is part of the repair machinery for DNA damage caused by ultraviolet light, has evolved an additional function in , allowing very short tracts of DNA-with a mean length of only 28 bp-to be imported into the genome during natural transformation.
幽门螺旋杆菌的基因组比任何经过研究的其他生物体都更频繁地通过同源重组而混合，导致种群内出现明显的“自由重组”。最近，F. Ailloud、I. Estibariz、G. Pfaffinger 和 S. Suerbaum 在 mBio 发表的一篇文章（13:e01811-22, 2022, https://doi.org/10.1128/mbio.01811-22）有助于阐明用于实现这种非同寻常的遗传交换率的细胞机制。具体来说，他们表明，UvrC 基因是修复由紫外线引起的 DNA 损伤的修复机制的一部分，在 中进化出了额外的功能，允许非常短的 DNA 片段（平均长度仅为 28bp）在自然转化过程中被导入基因组。
Zotero 插件