Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
Annu Rev Microbiol. 2011;65:329-48. doi: 10.1146/annurev-micro-090110-102931.
All organisms have pathways that repair the genome, ensuring their survival and that of their progeny. But these pathways also serve to diversify the genome, causing changes at the nucleotide, whole gene, and genome structure levels. Sequencing of bacteria has revealed wide allelic diversity and differences in gene content within the same species, highlighting the importance of understanding pathways of recombination and DNA repair. The human stomach pathogen Helicobacter pylori is an excellent model system for studying these pathways. H. pylori harbors major recombination and repair pathways and is naturally competent, facilitating its ability to diversify its genome. Elucidation of DNA recombination, repair, and diversification programs in this pathogen will reveal connections between these pathways and their importance to infection.
所有生物体都有修复基因组的途径，以确保其自身及其后代的生存。但这些途径也有助于基因组多样化，导致核苷酸、整个基因和基因组结构水平上的变化。对细菌进行测序揭示了同一物种中广泛的等位基因多样性和基因内容差异，突出了理解重组和 DNA 修复途径的重要性。人类胃部病原体幽门螺杆菌是研究这些途径的理想模型系统。幽门螺杆菌拥有主要的重组和修复途径，并且具有天然的感受态，这使其能够多样化其基因组。阐明该病原体中的 DNA 重组、修复和多样化程序将揭示这些途径之间的联系及其对感染的重要性。
