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老年人布鲁氏菌病:来自卡塔尔的一例报告。

Brucellosis in older person: a case report from Qatar.

机构信息

Department of Geriatric Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

出版信息

Aging Male. 2022 Dec;25(1):266-268. doi: 10.1080/13685538.2022.2138851.

Abstract

BACKGROUND

Brucellosis is a multisystem disease with a broad spectrum of non-specific symptoms that generally occur within three weeks but sometimes up to 3 months after inoculation. Human brucellosis is quite uncommon in Elderly in Qatar.

CASE REPORT

This report describes a case of Brucellosis in acute geriatric unit under Rumailah Hospital in Qatar. The patient was an 81-year-old Qatari Gentle man, functionally able to walk with minimal assistance and had mild cognitive impairment who presented with high-grade fever with chills, anorexia, low back pain and arthralgia for 10 days. The above complaints occurred often for 1 month and had fever intermittently. Lab investigations revealed as high CRP 117 mg/l, low Hb 9.1 g/dl and mild elevation in ALP (151 µ/l) with normal leukocyte and platelet count. His blood culture positive for with high brucella Antibody titter 1:1280. The diagnosis made as Brucellosis.

DISCUSSION

The clinical manifestations of Brucellosis are fever, night sweating, chills, arthralgia and loss of appetite. It seems pyrexia of unknown origin without other symptoms is most common presentation of Brucellosis in old age. The confirmation of Brucellosis made with serological tests, with significantly high titer, in the presence or absence of blood culture. Brucella antibody titers (≥1:160) are suggestive of active infection. Anemia and raised CRP and liver enzymes were the most prominent laboratory abnormalities in our patients. Previous study from Qatar reported that 41.7% had a history of raw milk consumption and 12.5% had a history of animal contact. The objectives of Brucellosis treatment include the prevention of complications and relapse.

CONCLUSION

Our case presented with classical symptoms and received appropriate treatment on time. However, atypical clinical presentation and lack of specific history taking can delay diagnosis and treatment; it leads to serious clinical disease progression with increased complications. From this case study, we would contribute to optimal assessment and to keep differential diagnosis for unknown cause of fever can be Brucellosis in geriatric population.

摘要

背景

布鲁氏菌病是一种多系统疾病,具有广泛的非特异性症状,通常在接种后 3 周内出现,但有时也会在 3 个月后出现。在卡塔尔,老年人患人类布鲁氏菌病的情况相当罕见。

病例报告

本报告描述了卡塔尔 Rumailah 医院急性老年病房的一例布鲁氏菌病病例。患者是一位 81 岁的卡塔尔男性,能够在最小帮助下行走,认知能力轻度受损,表现为高热寒战、食欲不振、腰痛和关节痛 10 天。上述症状经常持续 1 个月,并间歇性发热。实验室检查显示 CRP 升高至 117mg/L,Hb 降低至 9.1g/dl,碱性磷酸酶(ALP)轻度升高(151µ/l),白细胞和血小板计数正常。血液培养阳性,布鲁氏菌抗体滴度高,为 1:1280。诊断为布鲁氏菌病。

讨论

布鲁氏菌病的临床表现为发热、夜间出汗、寒战、关节痛和食欲不振。似乎没有其他症状的不明原因发热是老年人布鲁氏菌病最常见的表现。布鲁氏菌病的确诊通过血清学检查,在血液培养阳性或阴性的情况下,抗体滴度显著升高。布鲁氏菌抗体滴度(≥1:160)提示存在活动性感染。在我们的患者中,贫血和 CRP 和肝酶升高是最突出的实验室异常。来自卡塔尔的一项先前研究报告称,41.7%的人有饮用生奶的历史,12.5%的人有动物接触史。布鲁氏菌病治疗的目的包括预防并发症和复发。

结论

我们的病例表现出典型症状,并及时接受了适当的治疗。然而,不典型的临床表现和缺乏特定的病史采集可能会延迟诊断和治疗;这会导致严重的临床疾病进展,增加并发症的发生。从这个病例研究中,我们将有助于进行最佳评估,并保持对未知原因发热的鉴别诊断,老年人的发热可能是布鲁氏菌病。

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