Grigor'eva I N
Institute of Internal and Preventive Medicine - branch of the Institute of Cytology and Genetics.
Ter Arkh. 2022 Feb 15;94(2):265-270. doi: 10.26442/00403660.2022.02.201375.
This article provides an overview of the metaanalyzes (PubMed, 19952019) of alcohol and non-alcoholic (coffee, tea, dairy products) beverage consumption in relation to risk of pancreatic cancer PC (PubMed, 19952019). Increased the PC risk was associated with high alcohol intake. The increased risk for heavy drinking did not explained by residual confounding by history of pancreatitis or tobacco smoking or diabetes. Light-moderate alcohol intake may reduced the PC risk, probably due to the fasting insulin levels decrement, which leads to the diminished the РС risk. The association between alcohol and the PC was stronger in men than in women. Some metaanalyzes demonstrated that a small amount of coffee may reduce PC risk, and a large amount to increase PC risk. Another meta-analyzes have not confirmed any association between the PC risk and coffee or tea consumption. One meta-analysis revealed a direct association of the PC risk with the dairy products consumption, but most research showed no such connection. Nutrition is considered to be associated with the PC risk, but the degree of risk due to structure of beverages consumption (dose, duration, alcohol, coffee, tea, dairy products pattern) is still not clear.
本文概述了1995年至2019年期间关于酒精及非酒精饮料（咖啡、茶、乳制品）消费与胰腺癌（PC）风险关系的荟萃分析（PubMed数据库）。胰腺癌风险增加与高酒精摄入量相关。重度饮酒导致的风险增加不能用胰腺炎病史、吸烟史或糖尿病的残余混杂因素来解释。轻度至中度饮酒可能会降低胰腺癌风险，这可能是由于空腹胰岛素水平降低，从而降低了胰腺癌风险。酒精与胰腺癌之间的关联在男性中比在女性中更强。一些荟萃分析表明，少量咖啡可能会降低胰腺癌风险，而大量饮用则会增加胰腺癌风险。另一项荟萃分析未证实胰腺癌风险与咖啡或茶的消费之间存在任何关联。一项荟萃分析揭示了胰腺癌风险与乳制品消费之间存在直接关联，但大多数研究并未显示出这种联系。营养被认为与胰腺癌风险有关，但由于饮料消费结构（剂量、持续时间、酒精、咖啡、茶、乳制品模式）导致的风险程度仍不明确。
