Bordin D S, Shengelia M I, Ivanova V A, Voynovan I N
Loginov Moscow Clinical Scientific Center.
Yevdokimov Moscow State University of Medicine and Dentistry.
Ter Arkh. 2022 Feb 15;94(2):283-288. doi: 10.26442/00403660.2022.02.201377.
Helicobacter pylori is a spiral-shaped gram-negative bacterium that colonizes the stomach lining. The presence of a microorganism in humans was described more than a century ago, but from detection to recognition of its role in the etiology and pathogenesis of diseases of the stomach, researchers had to overcome a long path of criticism and mistrust. Coiled bacteria have been mentioned several times in the medical literature, but these bacteria were thought to be contaminants, and any evidence of the bacteria in the stomach was ignored by the medical community. The discovery of H. pylori led to a revolutionary rethinking of the mechanisms of development of a number of diseases: the role of bacteria in the development of chronic gastritis, peptic ulcer disease, stomach cancer and MALT lymphoma was proved. The principles of their prevention and treatment have changed. For this discovery in 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Medicine and Physiology.
幽门螺杆菌是一种定殖于胃黏膜的螺旋形革兰氏阴性菌。人类体内存在微生物这一情况在一个多世纪前就有描述，但从其被检测出来到认识到它在胃部疾病病因和发病机制中的作用，研究人员不得不克服漫长的质疑和不信任之路。卷曲状细菌在医学文献中曾被多次提及，但这些细菌被认为是污染物，医学界忽视了胃中存在这种细菌的任何证据。幽门螺杆菌的发现引发了对多种疾病发病机制的革命性重新思考：证实了细菌在慢性胃炎、消化性溃疡病、胃癌和黏膜相关淋巴组织淋巴瘤发病中的作用。它们的预防和治疗原则也发生了改变。由于这一发现，巴里·马歇尔和罗宾·沃伦于2005年被授予诺贝尔生理学或医学奖。
