前列腺癌生化复发 [Ga]Ga-PSMA-11 检测阴性，但 [F]氟甲基胆碱 PET/CT 检测阳性。
Prostate Cancer Biochemical Recurrence Resulted Negative on [Ga]Ga-PSMA-11 but Positive on [F]Fluoromethylcholine PET/CT.
机构信息
Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, 98125 Messina, Italy.
Department of Nuclear Medicine, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
出版信息
Tomography. 2022 Sep 30;8(5):2471-2474. doi: 10.3390/tomography8050205.
For prostate cancer (PCa) biochemical recurrence (BCR), the primarily suggested imaging technique by the European Association of Urology (EAU) guidelines is prostate-specific membrane antigen (PSMA) positron emission tomography/computer tomography (PET/CT). Indeed, the increased detection rate of PSMA PET/CT for early BCR has led to a fast and wide acceptance of this novel technology. However, PCa is a very heterogeneous disease, not always easily assessable with the highly specific PSMA PET with around 10% of cases occuring without PSMA expression. In this paper, we present the case of a patient with PCa BCR that resulted negative on [Ga]Ga-PSMA-11 PET/CT, but positive on [F]Fluoromethylcholine (Choline) PET/CT.
对于前列腺癌（PCa）生化复发（BCR），欧洲泌尿外科学会（EAU）指南主要推荐使用前列腺特异性膜抗原（PSMA）正电子发射断层扫描/计算机断层扫描（PET/CT）进行影像学检查。事实上，PSMA PET/CT 对早期 BCR 的检测率增加，导致这项新技术得到了快速广泛的认可。然而，PCa 是一种非常异质的疾病，并非总是可以用高度特异性的 PSMA PET 轻易评估，约有 10%的病例不表达 PSMA。本文报告了一例 PCa BCR 患者，[Ga]Ga-PSMA-11 PET/CT 结果为阴性，但[F]氟甲基胆碱（Choline）PET/CT 结果为阳性。
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