Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Toxins (Basel). 2022 Oct 20;14(10):715. doi: 10.3390/toxins14100715.
The cyanobacterial blooms produced by eutrophic water bodies have become a serious environmental issue around the world. After cellular lysing or algaecide treatment, microcystins (MCs), which are regarded as the most frequently encountered cyanobacterial toxins in fresh water, are released into water. Among all the variants of MCs, MC-LR has been widely studied due to its severe hepatotoxicity. Since 1992, various studies have identified the important roles of MC-LR in the origin and progression of primary liver cancers (PLCs), although few reviews have focused on it. Therefore, this review aims to summarize the major achievements and shortcomings observed in the past few years. Based on the available literature, the mechanisms of how MC-LR induces or promotes PLCs are elucidated in this review. This review aims to enhance our understanding of the role that MC-LR plays in PLCs and provides a rational approach for future applications.
富营养化水体产生的蓝藻水华已成为全球范围内的严重环境问题。细胞裂解或杀藻处理后，微囊藻毒素（MCs）被释放到水中，它们被认为是淡水环境中最常见的蓝藻毒素。在所有 MCs 的变体中，由于其严重的肝毒性，MC-LR 已被广泛研究。自 1992 年以来，各种研究已经确定了 MC-LR 在原发性肝癌（PLCs）起源和进展中的重要作用，尽管很少有综述关注这一点。因此，本综述旨在总结过去几年的主要研究成果和不足之处。基于现有文献，本综述阐述了 MC-LR 诱导或促进 PLCs 的机制。本综述旨在提高我们对 MC-LR 在 PLCs 中作用的理解，并为未来的应用提供合理的方法。
