癌症中的非编码 RNA

Key Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Essays Biochem. 2021 Oct 27;65(4):625-639. doi: 10.1042/EBC20200032.

Majority of the human genome is transcribed to RNAs that do not encode proteins. These non-coding RNAs (ncRNAs) play crucial roles in regulating the initiation and progression of various cancers. Given the importance of the ncRNAs, the roles of ncRNAs in cancers have been reviewed elsewhere. Thus, in this review, we mainly focus on the recent studies of the function, regulatory mechanism and therapeutic potential of the ncRNAs including microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA) and PIWI interacting RNA (piRNA), in different type of cancers.

大多数人类基因组被转录为不编码蛋白质的 RNA。这些非编码 RNA（ncRNA）在调控各种癌症的发生和发展中起着至关重要的作用。鉴于 ncRNA 的重要性，ncRNA 在癌症中的作用已在其他地方进行了综述。因此，在本综述中，我们主要关注 miRNA、lncRNA、circRNA 和 PIWI 相互作用 RNA（piRNA）等 ncRNA 的功能、调控机制和治疗潜力的最新研究，这些研究在不同类型的癌症中都有涉及。