Department of Dermatology, Faculty of Medicine, University of Antananarivo, Antananarivo 101, Madagascar.
Centre d'Infectiologie Charles Mérieux, University of Antananarivo, Antananarivo 101, Madagascar.
Med Mycol. 2022 Nov 12;60(11). doi: 10.1093/mmy/myac086.
Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients.
From March 2013 to January 2019, a descriptive prospective study on CBM patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200 mg was given to patients every day for ˃3 months. Results were assessed at the 6th and 12th months and classified as major responses, minor responses to treatment, or failure.
A total of 29 cases of CBM were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow-up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared with CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response.
These findings demonstrated that CBM lesions are recalcitrant and difficult to treat.
着色芽生菌病（CBM）是一种由几种色素真菌引起的皮肤和皮下组织慢性真菌感染。它在马达加斯加等热带和亚热带地区很常见。本研究主要讨论抗真菌治疗的效果，同时描述我们患者的 CBM 的流行病学、临床和病理特征。
从 2013 年 3 月至 2019 年 1 月，对 CBM 患者进行了一项描述性前瞻性研究。该研究包括接受至少 3 个月抗真菌治疗的 CBM 患者。每天给予患者伊曲康唑 200mg，持续时间大于 3 个月。在第 6 个月和第 12 个月评估结果，并将其分类为主要反应、治疗的次要反应或失败。
共纳入 29 例 CBM 患者。患者的平均年龄为 42.02 岁。他们主要在农村地区工作。感染男性更为常见。在伊曲康唑治疗的第 12 个月结束时，3 名患者出现主要反应，14 名患者治疗有轻微反应，12 名患者失访。CBM 对治疗的临床反应与 CBM 的严重程度和长期病程有关。与由 Cladophialophora 引起的 CBM 相比，由 Fonsecaea 引起的 CBM 表现出更大的临床反应。
这些发现表明 CBM 病变具有顽固性和难治性。
