既往治疗过的着色芽生菌病的临床方面：来自马达加斯加的病例系列。

Clinical aspects of previously treated chromoblastomycosis: A case series from Madagascar.

机构信息

Department of Dermatology, Faculty of Medicine Antananarivo, Antananarivo, Madagascar.

出版信息

Int J Infect Dis. 2020 Dec;101:228-232. doi: 10.1016/j.ijid.2020.09.1479. Epub 2020 Oct 2.

DOI:10.1016/j.ijid.2020.09.1479

PMID:33011283

Abstract

OBJECTIVE

To describe the clinical aspects of chromoblastomycosis (CBM) presented by patients who had received incomplete antifungal treatment before consultation.

METHODS

A prospective study of patients with clinically suspected CBM was performed between 2013 and 2018 in the Department of Dermatology at the University Hospital Antananarivo, and during consultation campaigns.

RESULTS

Patients develop CBM over a period of more than 10 years, and many will have already received antifungals prescribed by general practitioners before consulting with a dermatologist. Such treatment obviously modifies the clinical presentation. From the 63 CBM patients in this large study, we describe 12 patients who received oral antifungals (terbinafine, griseofulvine, itraconazole, fluconazole) before consultation. The most frequent clinical aspect presented by these patients was cicatricial lesions, which are characteristically smooth and non-elevated, and enlarge by peripheral extension, with atrophic scarring at the center.

CONCLUSION

Our study is the first to show that cicatricial lesions are a clinical aspect presented by CBM patients who received antifungals before presentation.

摘要

目的

描述在就诊前接受不完整抗真菌治疗的患者的着色芽生菌病（CBM）的临床特征。

方法

2013 年至 2018 年，在塔那那利佛大学医院皮肤科进行了一项疑似 CBM 的临床疑似患者的前瞻性研究，并在咨询活动期间进行了研究。

结果

患者在 10 多年的时间里发展为 CBM，并且许多患者在咨询皮肤科医生之前已经接受了全科医生开出的抗真菌药物治疗。这种治疗显然改变了临床特征。在这项大型研究中的 63 例 CBM 患者中，我们描述了 12 例在就诊前接受过口服抗真菌药（特比萘芬、灰黄霉素、伊曲康唑、氟康唑）治疗的患者。这些患者最常见的临床特征是瘢痕性病变，其特征是光滑且非隆起，通过周围扩展而增大，中心有萎缩性瘢痕。