N-（3-氯丙基）苯乙胺作为β-苯乙胺的一种潜在前体药物：在大鼠脑中的研究
N-(3-chloropropyl)phenylethylamine as a possible prodrug of beta-phenylethylamine: studies in the rat brain.
作者信息
Rao T S, Baker G B, Coutts R T
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(2-3):301-8. doi: 10.1016/0278-5846(87)90074-1.
PMID:3628834
Abstract
N-(3-Chloropropyl)phenylethylamine (CPPEA) was examined as a possible prodrug of the neuromodulator trace amine beta-phenylethylamine (PEA) in rat tissues. CPPEA produced sustained elevation of PEA levels in rat brain, blood and liver. Rat brain concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were decreased by administration of CPPEA.
摘要
N-(3-氯丙基)苯乙胺（CPPEA）作为神经调质痕量胺β-苯乙胺（PEA）在大鼠组织中的一种可能前体药物进行了研究。CPPEA使大鼠脑、血液和肝脏中的PEA水平持续升高。给予CPPEA后，大鼠脑中去甲肾上腺素、多巴胺和5-羟色胺的浓度降低。
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