胺类前药。
Prodrugs for amines.
作者信息
Simplício Ana L, Clancy John M, Gilmer John F
机构信息
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República - EAN, 2780-157 Oeiras, Portugal.
出版信息
Molecules. 2008 Mar 3;13(3):519-47. doi: 10.3390/molecules13030519.
The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A compilation of the most important approaches is presented in the form of a table, where the main advantages and disadvantages of each strategy are also referred.
这项工作的目的是回顾已发表的胺类前药生产策略。该综述分为两大类方法：一类依赖酶促激活，另一类利用生理化学条件来释放药物。最重要的方法以表格形式呈现，其中还提及了每种策略的主要优缺点。
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