患者报告的结局评估以及对 Transplantoux 有氧运动干预中体力活动促进因素和障碍的评估。
Patient-reported outcomes evaluation and assessment of facilitators and barriers to physical activity in the Transplantoux aerobic exercise intervention.
机构信息
Laboratory of Exercise and Health, Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland.
Abdominal Transplantation, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
出版信息
PLoS One. 2022 Oct 26;17(10):e0273497. doi: 10.1371/journal.pone.0273497. eCollection 2022.
BACKGROUND
Transplantoux's MVT exercise intervention prepares organ transplant recipients to cycle or hike up France's Mont Ventoux. We aimed to assess (i) MVT's effects on patient-reported outcomes (PROs) and (ii) perceived barriers and facilitators to physical activity.
METHODS
Using a hybrid design, a convenience sample of transplant recipients participating in MVT (n = 47 cycling (TxCYC); n = 18 hiking (TxHIK)), matched control transplant recipients (TxCON, n = 213), and healthy MVT participants (HCON, n = 91) completed surveys to assess physical activity (IPAQ), health-related quality of life (HRQOL; SF-36 and EuroQol VAS), mental health (GHQ-12), and depressive symptomatology, anxiety, and stress (DASS-21) at baseline, then after 3, 6 (Mont Ventoux climb), 9, and 12 months. TxCYC and TxHIK participated in a 6-month intervention of individualized home-based cycling/hiking exercise and a series of supervised group training sessions. Barriers and facilitators to physical activity (Barriers and Motivators Questionnaire) were measured at 12 months.
RESULTS
Regarding PROs, except for reducing TxHIK stress levels, MVT induced no substantial intervention effects. For both TxCYC and TxHIK, between-group comparisons at baseline showed that physical activity, HRQOL, mental health, depressive symptomatology and stress were similar to those of HCON. In contrast, compared to TxCYC, TxHIK, and HCON, physical activity, HRQOL and mental health were lower in TxCON. TxCON also reported greater barriers, lower facilitators, and different priority rankings concerning physical activity barriers and facilitators.
CONCLUSION
Barely any of the PROs assessed in the present study responded to Transplantoux's MVT exercise intervention. TxCON reported distinct and unfavorable profiles regarding PROs and barriers and facilitators to physical activity. These findings can assist tailored physical activity intervention development.
TRIAL REGISTRATION
Clinical trial notation: The study was approved by the University Hospitals Leuven's Institutional Review Board (B322201523602).
背景
Transplantoux 的 MVT 运动干预方案旨在帮助器官移植受者为攀登法国旺度山（Mont Ventoux）而进行骑行或徒步训练。本研究旨在评估：（i）MVT 对患者报告结局（PROs）的影响；（ii）身体活动的感知障碍和促进因素。
方法
采用混合设计，选择参加 MVT 的移植受者（骑行组 n=47，TxCYC；徒步组 n=18，TxHIK）、匹配的移植对照受者（TxCON，n=213）和健康的 MVT 参与者（HCON，n=91）作为便利样本，使用国际体力活动问卷（IPAQ）、健康相关生活质量（SF-36 和 EuroQol VAS）、心理健康（GHQ-12）和抑郁、焦虑和压力症状（DASS-21）评估在基线、3、6 个月（攀登旺度山）、9 和 12 个月的情况。TxCYC 和 TxHIK 参加了为期 6 个月的个体化家庭骑行/徒步运动干预和一系列监督小组训练课程。在 12 个月时测量身体活动的障碍和促进因素（障碍和促进因素问卷）。
结果
就 PROs 而言，除了降低 TxHIK 的压力水平外，MVT 并未产生实质性的干预效果。在基线时，与 TxCYC 和 TxHIK 进行组间比较的结果显示，与 HCON 相比，身体活动、HRQOL、心理健康、抑郁症状和压力相似。相比之下，与 TxCYC、TxHIK 和 HCON 相比，TxCON 的身体活动、HRQOL 和心理健康水平较低。TxCON 还报告了更多的障碍、较低的促进因素，以及对身体活动障碍和促进因素的不同优先级排序。
结论
本研究评估的 PROs 几乎没有对 Transplantoux 的 MVT 运动干预方案产生反应。TxCON 报告了与 PROs 以及身体活动障碍和促进因素相关的独特和不利特征。这些发现可以为量身定制的身体活动干预措施的发展提供参考。
试验注册
临床试验注释：该研究得到了鲁汶大学附属医院伦理审查委员会（B322201523602）的批准。
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