Devkar Heena U, Thakur Narsinh L, Kaur Parvinder
CSIR- National Institute of Oceanography, Dona Paula 403004, Goa, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India.
Can J Microbiol. 2023 Jan 1;69(1):1-16. doi: 10.1139/cjm-2022-0147. Epub 2022 Oct 26.
Antimicrobial resistance (AMR) is one of the leading global health issues that demand urgent attention. Very soon the world will have to bear the consequences of increased drug resistance if new anti-infectives are not pumped into the clinical pipeline in a short period. This presses on the need for novel chemical entities, and the marine environment is one such hotspot to look for. The Ocean harbours a variety of organisms, of which from this aspect, "Sponges (Phylum Porifera)" are of particular interest. To tackle the stresses faced due to their sessile and filter-feeding lifestyle, sponges produce various bioactive compounds, which can be tapped for human use. The sponges harbour several microorganisms of different types and in most cases; the microbial symbionts are the actual producers of the bioactive compounds. This review describes the alarming need for the development of new antimicrobials and how marine sponges can contribute to this. Selected antimicrobial compounds from the marine sponges and their associated bacteria have been described. Additionally, measures to tackle the supply problem have been covered, which is the primary obstacle in marine natural product drug discovery.
抗菌耐药性（AMR）是全球主要的健康问题之一，亟待关注。如果不能在短期内将新的抗感染药物投入临床研发，世界很快将不得不承受耐药性增加带来的后果。这凸显了对新型化学实体的需求，而海洋环境就是寻找此类实体的热点之一。海洋中栖息着各种各样的生物，从这方面来看，“海绵动物（多孔动物门）”尤为引人关注。为应对因其固着和滤食性生活方式所面临的压力，海绵会产生各种生物活性化合物，这些化合物可供人类利用。海绵体内有多种不同类型的微生物，在大多数情况下，微生物共生体才是生物活性化合物的实际生产者。本综述描述了开发新型抗菌药物的迫切需求，以及海洋海绵如何能为此做出贡献。已介绍了从海洋海绵及其相关细菌中筛选出的抗菌化合物。此外，还探讨了解决供应问题的措施，而供应问题是海洋天然产物药物研发的主要障碍。
