Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Peking University Fifth School of Clinical Medicine, Beijing, China.
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Dig Liver Dis. 2023 Jul;55(7):848-855. doi: 10.1016/j.dld.2022.09.022. Epub 2022 Oct 23.
The risk of metabolic disease in adulthood is not only attributed to an unhealthy lifestyle after birth but also to famine exposure during the foetal period. This systematic review and meta-analysis aimed to evaluate the effects of foetal exposure to famine as a risk factor for developing nonalcoholic fatty liver disease (NAFLD) in adulthood.
Studies were retrieved from PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases to evaluate the effect of foetal exposure to famine on the risk of nonalcoholic fatty liver disease in adulthood.
Six studies involving 90,582 subjects were included in this meta-analysis. Foetal exposure to famine was associated with an increased risk of NAFLD(RR = 1.17, 95% CI: 1.08-1.27, P < 0.0001). Exposure to famine during the foetal period significantly increased the incidence of NAFLD in women (RR = 1.27, 95% CI: 1.16-1.40, P <0.00001), while similar results were not observed in the male subgroup (RR =0.99, 95% CI: 0.89-1.11, P = 0.88). Foetal exposure to famine was associated with the risk of mild NAFLD (RR = 1.17, 95% CI: 1.02-1.33, P = 0.02) and moderate to severe NAFLD (RR = 1.51, 95% CI: 1.16-1.98, P = 0.002).
Foetal exposure to famine is associated with an increased risk of NAFLD in adulthood. Women with NAFLD and moderate to severe NAFLD have a more robust association with foetal exposure to famine.
成年人患代谢疾病的风险不仅归因于出生后不健康的生活方式，还归因于胎儿期暴露于饥荒。本系统评价和荟萃分析旨在评估胎儿期暴露于饥荒作为成年人患非酒精性脂肪肝（NAFLD）的风险因素的影响。
从 PubMed、Embase、Cochrane 图书馆、Web of Science、中国知网（CNKI）和万方数据库检索研究，以评估胎儿期暴露于饥荒对成年人患非酒精性脂肪肝的风险的影响。
本荟萃分析纳入了 6 项研究，共涉及 90582 名受试者。胎儿期暴露于饥荒与 NAFLD 的风险增加相关（RR=1.17，95%CI：1.08-1.27，P<0.0001）。胎儿期暴露于饥荒显著增加了女性 NAFLD 的发生率（RR=1.27，95%CI：1.16-1.40，P<0.00001），但在男性亚组中未观察到类似结果（RR=0.99，95%CI：0.89-1.11，P=0.88）。胎儿期暴露于饥荒与轻度 NAFLD 的风险相关（RR=1.17，95%CI：1.02-1.33，P=0.02）和中重度 NAFLD 的风险相关（RR=1.51，95%CI：1.16-1.98，P=0.002）。
胎儿期暴露于饥荒与成年人患 NAFLD 的风险增加有关。患有 NAFLD 和中重度 NAFLD 的女性与胎儿期暴露于饥荒的相关性更强。
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