Tuncel Fatıma Ceren, Serin Istemi, Pehlivan Sacide, Oyaci Yasemin, Pehlivan Mustafa
Department of Medical Biology, Faculty of Medicine, Institute of Health Sciences, Istanbul University, Istanbul, Turkey.
Department of Hematology, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Blood Res. 2022 Dec 31;57(4):250-255. doi: 10.5045/br.2022.2022097. Epub 2022 Oct 27.
The suppressor of cytokine signaling-1 (SOCS-1) functions to induce an appropriate immune response and is an essential physiological regulator of interferon signaling. DNA methylation involves adding a methyl group to the carbon 5 position of cytosine. Besides comparing SOCS-1 gene methylation status between patients with multiple myeloma (MM) and healthy controls, this study also aimed to demonstrate the effect of SOCS-1 gene distribution and the effect of methylation of SOCS-1 on progression-free survival (PFS) and overall survival (OS).
This study included 120 patients diagnosed with MM between January 2018 and 2020 and 80 healthy individuals. The distribution of the SOCS-1 genotypes was statistically compared between MM patients and healthy controls. Additionally, the statistically significant effects of these genotypes on survival were examined.
The CA/CA genotype of SOCS-1 was significantly higher in healthy controls (=0.001), while the Del/Del genotype was significantly higher in patients with MM (=0.034). The percent methylated reference (PMR) value of the SOCS-1 gene was significantly higher in the healthy controls (median, 43.48; range, 2.76‒247.75; =0.001). Patients with a PMR value of ≥43.48 were 3.125 times more likely to develop progression than those with a PMR value of ＜43.48.
The effects of SOCS-1 polymorphisms on the pathogenesis of.
细胞因子信号转导抑制因子1（SOCS-1）在诱导适当的免疫反应中发挥作用，是干扰素信号传导的重要生理调节因子。DNA甲基化是指在胞嘧啶的5号碳位添加一个甲基基团。除了比较多发性骨髓瘤（MM）患者和健康对照者之间的SOCS-1基因甲基化状态外，本研究还旨在证明SOCS-1基因分布的影响以及SOCS-1甲基化对无进展生存期（PFS）和总生存期（OS）的影响。
本研究纳入了2018年1月至2020年期间确诊为MM的120例患者和80名健康个体。对MM患者和健康对照者之间的SOCS-1基因型分布进行统计学比较。此外，还检查了这些基因型对生存的统计学显著影响。
健康对照者中SOCS-1的CA/CA基因型显著更高（=0.001），而MM患者中Del/Del基因型显著更高（=0.034）。健康对照者中SOCS-1基因的甲基化参考百分比（PMR）值显著更高（中位数为43.48；范围为2.76‒247.75；=0.001）。PMR值≥43.48的患者发生疾病进展的可能性是PMR值＜43.48患者的3.125倍。
SOCS-1多态性对……发病机制的影响。
