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Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways.

作者信息

Cousins A, Olivares O, Markert E, Manoharan A, Bubnova X, Bresolin S, Degn M, Li Z, Silvestri D, McGregor G, Tumanov S, Sumpton D, Kamphorst J J, Michie A M, Herzyk P, Valsecchi M G, Yeoh A E, Schmiegelow K, Te Kronnie G, Gottlieb E, Halsey C

机构信息

Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Cancer Research UK Beatson Institute, Glasgow, UK.

出版信息

Leukemia. 2022 Dec;36(12):2903-2907. doi: 10.1038/s41375-022-01722-x. Epub 2022 Oct 26.

DOI:10.1038/s41375-022-01722-x
PMID:36289348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9712090/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83b/9712090/98a7461ac26d/41375_2022_1722_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83b/9712090/e8802d28766e/41375_2022_1722_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83b/9712090/98a7461ac26d/41375_2022_1722_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83b/9712090/e8802d28766e/41375_2022_1722_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83b/9712090/98a7461ac26d/41375_2022_1722_Fig2_HTML.jpg

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Nat Cancer. 2020 Oct;1(10):998-1009. doi: 10.1038/s43018-020-00115-2. Epub 2020 Sep 28.
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Dyslipidemia at diagnosis of childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病诊断时的血脂异常。
PLoS One. 2020 Apr 6;15(4):e0231209. doi: 10.1371/journal.pone.0231209. eCollection 2020.
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Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor.
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