Muth Daniel Rudolf, Toro Mario Damiano, Bajka Anahita, Jonak Kamil, Rieder Roman, Kohler Myrtha Magdalena, Gunzinger Jeanne Martine, Souied Eric H, Engelbert Michael, Freund K Bailey, Zweifel Sandrine Anne
Department of Ophthalmology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland.
University of Zurich (UZH), 8006 Zurich, Switzerland.
Biomedicines. 2022 Sep 22;10(10):2370. doi: 10.3390/biomedicines10102370.
To investigate associations and predictive factors between macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naïve neovascular age-related macular degeneration (AMD). Methods: Multimodal imaging was retrospectively reviewed for druse type (soft drusen, subretinal drusenoid deposits (SDDs) or mixed) and MNV type (MNV 1, MNV 2, MNV 1/2 or MNV 3). The Consensus on Neovascular AMD Nomenclature (CONAN) classification was used for characterizing MNV at baseline. Results: One eye of each eligible patient was included (n = 191). Patients with predominant SDDs had an increased adjusted odds ratio (aOR) for MNV 2 (23.4453, p = 0.0025) and any type of MNV 3 (8.7374, p < 0.0001). Patients with MNV 1/2 had an aOR for predominant SDDs (0.3284, p = 0.0084). Patients with MNV1 showed an aOR for SDDs (0.0357, p < 0.0001). Eyes with SDDs only without other drusen types showed an aOR for MNV 2 (9.2945, p < 0.0001). Conclusions: SDDs represent a common phenotypic characteristic in AMD eyes with treatment-naïve MNV. The aOR for eyes with predominant SDDs to develop MNV 2 and MNV 3 was much higher, possibly due to their location in the subretinal space. The predominant druse type may help to predict which type of MNV will develop during the course of AMD.
探讨初治新生血管性年龄相关性黄斑变性（AMD）患者黄斑新生血管（MNV）病变亚型与玻璃膜疣类型之间的关联及预测因素。方法：对玻璃膜疣类型（软性玻璃膜疣、视网膜下玻璃膜疣样沉积物（SDD）或混合型）和MNV类型（MNV 1、MNV 2、MNV 1/2或MNV 3）进行回顾性多模态成像分析。采用新生血管性AMD命名共识（CONAN）分类法在基线时对MNV进行特征描述。结果：纳入每位符合条件患者的一只眼（n = 191）。以SDD为主的患者发生MNV 2的调整优势比（aOR）升高（23.4453，p = 0.0025），以及发生任何类型MNV 3的aOR升高（8.7374，p < 0.0001）。患有MNV 1/2的患者发生以SDD为主的aOR为（0.3284，p = 0.0084）。患有MNV1的患者发生SDD的aOR为（0.0357, p < 0.0001）。仅存在SDD而无其他玻璃膜疣类型的眼发生MNV 2的aOR为（9.2945，p < 0.0001）。结论：SDD是初治MNV的AMD眼中的常见表型特征。以SDD为主的眼发生MNV 2和MNV 3的aOR要高得多，可能是由于它们位于视网膜下间隙。主要的玻璃膜疣类型可能有助于预测AMD病程中会发生哪种类型的MNV。
