Lavorgna Tessa R, Hussein Mohammad, Issa Peter P, Toraih Eman, Kandil Emad
School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Department of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Biomedicines. 2022 Oct 1;10(10):2452. doi: 10.3390/biomedicines10102452.
Ultraviolet (UV) light has been reported to have both pro-oncogenic and anti-oncogenic effects. Since patient pigmentation can influence the role of UV light exposure, we thought to investigate the recent trends in thyroid cancer incidence and survival with an emphasis on patient race and UV exposure. Patients diagnosed with thyroid cancer from the Surveillance, Epidemiology, and End Results (SEER) database were identified. A total of 284,178 patients were enrolled. Data were stratified according to population sex, race, and state. UV exposure data in Watt-Hours Per Square Meter for the state were obtained from the National Cancer Institute Cancer Atlas. Thyroid cancer incidence rate varied by race, ranging from 14.9 cases per 100,000 in Asian or Pacific Islanders and 14.7 per 100,000 in Caucasians, to 8.7 per 100,000 in African American and 8.0 per 100,000 in Native Americans. UV exposure was negatively correlated with thyroid cancer incidence when analyzed across all populations (r = −0.299, p = 0.035). UV exposure was most steeply negatively correlated with thyroid cancer rates in Black populations (r = −0.56, p < 0.001). Despite this, Black men had the worst 5-year survival rate when compared to other ethnic populations. Overall, UV exposure does not increase the risk of thyroid cancer and may serve as a protective factor in the development of thyroid cancer.
据报道，紫外线（UV）具有促癌和抗癌两种作用。由于患者的色素沉着会影响紫外线暴露的作用，我们认为有必要调查甲状腺癌发病率和生存率的近期趋势，重点关注患者种族和紫外线暴露情况。我们从监测、流行病学和最终结果（SEER）数据库中确定了被诊断为甲状腺癌的患者。总共纳入了284178名患者。数据根据人群的性别、种族和所在州进行分层。该州每平方米瓦时的紫外线暴露数据来自美国国家癌症研究所癌症地图集。甲状腺癌发病率因种族而异，从亚洲或太平洋岛民的每10万人14.9例、白种人的每10万人14.7例，到非裔美国人的每10万人8.7例和美洲原住民的每10万人8.0例不等。在对所有人群进行分析时，紫外线暴露与甲状腺癌发病率呈负相关（r = -0.299，p = 0.035）。在黑人人群中，紫外线暴露与甲状腺癌发病率的负相关性最为显著（r = -0.56，p < 0.001）。尽管如此，与其他种族人群相比，黑人男性的5年生存率最差。总体而言，紫外线暴露不会增加甲状腺癌的风险，可能是甲状腺癌发生发展的一个保护因素。
