School of Public Health, Zhejiang Chinese Medical University.
Emergency Medical Center, Ningbo Yinzhou No. 2 Hospital.
J Nutr Sci Vitaminol (Tokyo). 2021;67(5):273-282. doi: 10.3177/jnsv.67.273.
The correlation between vitamin D intake and lung cancer development is controversial. This meta-analysis aims to evaluate the relationship between vitamin D and the prognosis and incidence of lung cancer. A comprehensive database search on PubMed, Web of Science, EBSCO, and Cochrane Library was carried out from the beginning to November 2020. Long-term survival and the incidence rate of patients with lung cancer were the primary outcomes of the study. Ten eligible studies were selected for the meta-analysis following specific inclusion and exclusion criteria. Four included studies, covering 5,007 patients, compared the overall survival (OS) and relapse-free survival (RFS) of lung cancer patients among total vitamin D users with non-users. Significantly, the estimated pooled hazard ratio (HR) revealed that vitamin D could improve OS and RFS of lung cancer patients [HR=0.83, 95% CI (0.72-0.95); HR=0.79, 95% CI (0.61-0.97), respectively]. Vitamin D intake was inversely associated with lung cancer incidence in six studies [OR=0.90, 95% CI (0.83-0.97)]. The present meta-analysis shows vitamin D not only improves the long-term survival of lung cancer patients but has a beneficial effect on the incidence of lung cancer. Notwithstanding, more studies are needed to confirm the study results.
维生素 D 摄入与肺癌发展之间的相关性存在争议。本荟萃分析旨在评估维生素 D 与肺癌预后和发病率之间的关系。从开始到 2020 年 11 月，我们在 PubMed、Web of Science、EBSCO 和 Cochrane Library 上进行了全面的数据库搜索。患者的长期生存和肺癌发病率是本研究的主要结局。根据具体的纳入和排除标准，选择了 10 项符合条件的研究进行荟萃分析。其中 4 项研究纳入了 5007 例患者，比较了总维生素 D 用户与非用户肺癌患者的总生存率（OS）和无复发生存率（RFS）。有意义的是，估计的合并风险比（HR）表明维生素 D 可以改善肺癌患者的 OS 和 RFS [HR=0.83，95% CI（0.72-0.95）；HR=0.79，95% CI（0.61-0.97）]。6 项研究表明，维生素 D 摄入与肺癌发病率呈负相关[OR=0.90，95% CI（0.83-0.97）]。本荟萃分析表明，维生素 D 不仅可以改善肺癌患者的长期生存，而且对肺癌的发病率也有有益的影响。尽管如此，仍需要更多的研究来证实研究结果。
